| Yan Nan,Zhou Yun,Sun Xiangshang,et al.Influence of selection of domain shape on parameters of microdosimetric kinetic model[J].Chinese Journal of Radiological Medicine and Protection,2023,43(3):209-215 |
| Influence of selection of domain shape on parameters of microdosimetric kinetic model |
| Received:September 06, 2022 |
| DOI：10.3760/cma.j.cn112271-20220906-00364 |
| KeyWords:Microdosimetric kinetic model Dose-averaged specific energy Domain Linear energy transfer |
| FundProject:国家重点研发计划（2016YFC0105400） |
| Author Name | Affiliation | E-mail | | Yan Nan | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
University of Chinese Academy of Sciences, Beijing 100049, China | | | Zhou Yun | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
University of Chinese Academy of Sciences, Beijing 100049, China | | | Sun Xiangshang | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
University of Chinese Academy of Sciences, Beijing 100049, China | | | Liao Wentao | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
University of Chinese Academy of Sciences, Beijing 100049, China | | | Liu Junya | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
University of Chinese Academy of Sciences, Beijing 100049, China | | | Pu Yuehu | Medical equipment Innovation Research Center, West China Hospital, Sichuan University, Chengdu 610041, China | puyuehu@163.com |
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| Abstract:: |
| Objective To calculate the single-event dose-averaged specific energy of particles delivered in spherical domains based on the track structure model and using triple integration, and to investigate the influence of the domain shape on the key model parameters of microdosimetric kinetic model (MKM) and its corresponding physical significance.Methods The domains are assumed to be cylinders and spheres, respectively. With α0, domain radius, rd, and nucleus radius, Rn, as undetermined coefficients, the nuclear charge numbers, kinetic energies and their corresponding LETs of three kinds of charged particles (3He, 12C, 20Ne) as independent variables, D10 as dependent variable, the mean value of squared residuals, J2, between the D10 calculated values and D10 experimental values as the optimization objective, the final fitting values of the above undetermined coefficients of human salivary gland (HSG) cells and Chinese hamster lung (V79) cells obtained after iteration by the robust least square method are the optimal model parameter values of MKM.Results For HSG cells, cylindrical domain:α0=0.073/Gy, rd=0.29 μm, Rn=4.1 μm, J2=0.039 7 Gy2; spherical domain:α0=0.023/Gy, rd=0.29 μm, Rn=4.4 μm, J2=0.039 3 Gy2; For V79 cells, cylindrical domain:α0=0.114/Gy, rd=0.25 μm, Rn=3.8 μm, J2=0.097 4 Gy2; spherical domain:α0=0.095/Gy, rd=0.26 μm, Rn=4.1 μm, J2=0.096 9 Gy2.Conclusions For the same type of cells, cylindrical and spherical domains were selected respectively, and there are significant differences in MKM parameters obtained by fitting. The fitting values of the domain radius, rd of the two shapes of domains show no significant difference, while the fitting values of α0 of spherical domains are smaller than those of cylindrical domains, the fitting values of nucleus radius, Rn, of spherical domain are larger than those of cylindrical domains, closer to the nucleus radius observed by fluorescence microscopy. In the low LET (<20 keV/μm) region, D10 calculated according to the parameters of the two different shapes of domains are different, so the selection of the domain shape will cause differences in the relative biological effectiveness(RBE) calculation of proton in the region near Bragg peak. |
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