| Zhou Guiqiang,Xue Yizhe,Zhang Zhaowen,et al.Effect of radiofrequency radiation from 5G mobile phone on blood-brain barrier in mice[J].Chinese Journal of Radiological Medicine and Protection,2023,43(3):176-181 |
| Effect of radiofrequency radiation from 5G mobile phone on blood-brain barrier in mice |
| Received:October 25, 2022 |
| DOI：10.3760/cma.j.cn112271-20221025-00418 |
| KeyWords:5G mobile phone Radio frequency radiation Mice Blood brain barrier |
| FundProject:空军军医大学专项课题（2021HKYX08） |
| Author Name | Affiliation | E-mail | | Zhou Guiqiang | School of Public Health, Weifang Medical University, Weifang 261053, China | | | Xue Yizhe | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Zhang Zhaowen | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Qin Tongzhou | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Guo Ling | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Lai Panpan | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Gao Peng | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Wang Xing | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Huang Zhifei | School of Public Health, Weifang Medical University, Weifang 261053, China | | | Zang Yuhang | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Jing Yuntao | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | | | Ding Guirong | Department of Radiation Protection Medicine, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China | dingzhao@fmmu.edu.cn |
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| Abstract:: |
| Objective To investigate the effect of radiofrequency radiation (RF) from 5G mobile phone communication frequency bands (3.5 GHz and 4.9 GHz) on the permeability of the blood-brain barrier (BBB) in mice.Methods A total of 24 healthy adult male C57BL/6 mice (6-8 weeks old) were randomly divided into Sham, 3.5 GHz RF and 4.9 GHz RF groups, and 8 mice in each group. Mice in the RF groups were systemically exposed to 5G cell phone radiation for consecutive 35 d(1 h/d) with 50 W/m2 power density. The BBB permeability of mice was detected by Evans Blue (EB) fluorescence experiment. The expression levels of the BBB tight junction-related proteins (ZO-1, occludin and claudin-11) and the gap junction-related protein Connexin 43 were determined by Western blot.Results The number of spots, fluorescence intensity and comprehensive score of EB were significantly increased in 3.5 GHz RF group and 4.9 GHz RF group compared with the Sham group (t=12.98, 17.82, P < 0.001). Compared with the Sham group, the content of S100B in mouse serum was significantly increased in 3.5 GHz RF group and 4.9 GHz RF group (t=19.34, 14.68, P < 0.001). The BBB permeability was increased in the RF group. The expression level of occludin protein was significantly reduced in the 3.5 GHz RF group (t=-3.13, P < 0.05), and this decrease was much profound in the 4.9 GHz RF group (t=-6.55, P < 0.01). But the protein levels of ZO-1, Claudin-11 and Connexin 43 in the cerebral cortex of the RF groups had no significantly difference in comparison with the Sham group(P > 0.05).Conclusions The continuous exposure of mobile phone RF at 3.5 GHz or 4.9 GHz for 35 d (1 h/d) induces an increase of BBB permeability in the mouse cerebral cortex, perhaps by reducing the expression of occludin protein. |
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