| Wei Jinling,Zhang Yong,Pan Xinyan,Wang Li.Research progress of the roles of metabolic reprogramming in radiation-induced direct- and bystander-effects[J].Chinese Journal of Radiological Medicine and Protection,2023,43(2):154-160 |
| Research progress of the roles of metabolic reprogramming in radiation-induced direct- and bystander-effects |
| Received:June 28, 2022 |
| DOI：10.3760/cma.j.cn112271-20220628-00269 |
| KeyWords:Ionizing Radiation Radiation-induced bystander effect Metabolomics Metabolic reprogramming |
| FundProject:国家自然科学基金（81860557）；云南省科技基金（202101AY070001-102，202201AY070001-240） |
| Author Name | Affiliation | E-mail | | Wei Jinling | Department of Pathology, Affiliated Hospital of Kunming University of Science and Technology, First People's Hospital of Yunnan Province, Kunming 650032, China | | | Zhang Yong | Department of Radiation Oncology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | | | Pan Xinyan | Department of Pathology, Yunnan First People's Hospital, Kunming 650000, China | | | Wang Li | Department of Pathology, Yunnan First People's Hospital, Kunming 650000, China | 2001wl@163.com |
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| Abstract:: |
| Metabolic reprogramming refers to the phenomenon that tumor cells, in order to meet their own growth and energy needs, regulate their biological functions by changing their metabolic mode, help themselves resist external stresses, and thus enable cells to adapt to hypoxia, acid, nutrient deficiency and other microenvironments and rapidly proliferate. It was found that metabolic reprogramming could contribute to radiation resistance and it also could be induced in bystander cells which may result in radiation resistance and the cancellation. Investigation the mechanism of radiation-induced metabolic reprogramming may provide new ideas and a theoretical framework for radiation protection, radiotherapy, and radio-diagnosis. This article reviewed the research progress on the mechanism of metabolic reprogramming in the direct and bystander effects of radiation. |
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