| Chen Jie,Tian Mei,Gao Ling.Research progress on the role and mechanism of premature cellular senescence on wound healing in radiation-induced skin injury[J].Chinese Journal of Radiological Medicine and Protection,2023,43(2):149-153 |
| Research progress on the role and mechanism of premature cellular senescence on wound healing in radiation-induced skin injury |
| Received:September 19, 2022 |
| DOI：10.3760/cma.j.cn112271-20220919-00378 |
| KeyWords:Ionizing radiation Premature cellular senescence Radiation-induced skin injury Wound healing |
| FundProject:北京市自然科学基金（7202139，7162137）；国家自然科学基金（31570852） |
| Author Name | Affiliation | E-mail | | Chen Jie | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Tian Mei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gao Ling | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | gaoling@nirp.chinacdc.cn |
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| Abstract:: |
| Radiation skin injury can be induced by medical exposure, occupational exposure, and emergency exposure. Many relevant studies focused on the prevention and treatment of radiation-induced skin injury, but the underlying molecular mechanisms have not been fully clarified. It has been demonstrated that radiation-induced premature cellular senescence is involved in radiation skin injury. To discuss the relationship between radiation-induced premature cellular senescence and radiation-induced skin injury, this paper reviewed the mechanism of radiation-induced skin injury, the promotion of premature cellular senescence and related signal pathways, and the role of premature cellular senescence in wound healing. |
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