| Wang Yunhan,Sun Yanan,Li Peng,Yang Jianwei,Wang Xiaohui,Zhang Zhenqin,Zheng Xiaoli,Luo Hui,Ye Ke,Ge Hong.Prognostic value of metabolic parameters of 18F-FDG PET/CT in advanced non-small cell lung cancer treated with first-line immunotherapy combined with chemotherapy[J].Chinese Journal of Radiological Medicine and Protection,2023,43(2):87-93 |
| Prognostic value of metabolic parameters of 18F-FDG PET/CT in advanced non-small cell lung cancer treated with first-line immunotherapy combined with chemotherapy |
| Received:August 10, 2022 |
| DOI：10.3760/cma.j.cn112271-20220810-00327 |
| KeyWords:18F-FDG Immunotherapy combined with chemotherapy Total metabolic tumor volume |
| FundProject:河南省科技攻关项目（222102310015）；河南省医学科技攻关项目（SBGJ202102056） |
| Author Name | Affiliation | E-mail | | Wang Yunhan | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Sun Yanan | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Li Peng | PET/CT Center of Henan Province, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Yang Jianwei | PET/CT Center of Henan Province, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Wang Xiaohui | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Zhang Zhenqin | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Zheng Xiaoli | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Luo Hui | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Ye Ke | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | | | Ge Hong | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China | gehong666@126.com |
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| Abstract:: |
| Objective To investigate the prognostic value of metabolic parameters of 18F-fluorodeoxyglucose (18F-FDG) positron emission computed tomography/computed tomography(PET/CT) in advanced non-small cell lung cancer(NSCLC) treated with first-line immune checkpoint inhibitor (ICI) combined with chemotherapy.Methods A retrospective study was conducted to evaluate patients with advanced NSCLC who underwent baseline PET/CT before treatment at the Affiliated Cancer Hospital of Zhengzhou University from 2019 to 2021. Receiver operating characteristic (ROC) curve analysis was used to determine the cut-offs for metabolic parameters of PET/CT, including total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximum standard uptake value (SUVmax). Kaplan-Meier method, Log-rank test, and Cox regression model were used to calculate the overall survival (OS) and the progression-free survival(PFS).Results A total of 44 patients were enrolled. Univariate analysis showed that the factors influencing PFS were TMTV and the number of metastatic sites (χ2=4.19, 11.28,P<0.05) and the factors influencing OS were TMTV and TLG (χ2=14.96, 6.05,P<0.05). Multivariate analysis suggested that number of metastatic sites was an independent prognostic marker for PFS (P=0.011) and TMTV was an independent prognostic marker for OS (P=0.038).Conclusions TMTV is a prognostic indicator of OS while the number of metastatic sites is a prognostic indicator of PFS in advanced NSCLC patients who received first-line ICI combined with chemotherapy, but further prospective studies are needed. |
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