| Deng Xianzhi,Chen Jing,Lin Zhanghua,Li Nuoxi,Dong Fangfen,He Shanting,Zhang Jianping,Xu Benhua,Ma Jiajun,Li Xiaobo.Experimental study of percutaneous transhepatic implantation of recoverable fiducial marker in Cyberknife tracking therapy[J].Chinese Journal of Radiological Medicine and Protection,2023,43(2):81-86 |
| Experimental study of percutaneous transhepatic implantation of recoverable fiducial marker in Cyberknife tracking therapy |
| Received:November 08, 2022 |
| DOI：10.3760/cma.j.cn112271-20221108-00440 |
| KeyWords:Recoverable fiducial marker Percutaneous transhepatic implantation Cyberknife Rabbit |
| FundProject:福建省医学创新课题（2020CXA026）；福建省卫生健康青年科研课题（2002QNA027） |
| Author Name | Affiliation | E-mail | | Deng Xianzhi | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Chen Jing | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Lin Zhanghua | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Li Nuoxi | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Dong Fangfen | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | He Shanting | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Zhang Jianping | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Xu Benhua | School of Medical Imaging, Fujian Medical University, Fujian Medical University Cancer Center, Fujian Key Laboratory of Intelligence Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Ma Jiajun | Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China | | | Li Xiaobo | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou 350001, China
Department of Engineering Physics, Tsinghua University, Beijing 100084, China | lixiaobo2004@126.com |
|
| Hits: 1787 |
| Download times: 367 |
| Abstract:: |
| Objective To evaluate the feasibility of a novel liver fiducial marker implantation method for internal fixation and removal of rabbit livers, in order to use in Cyberknife tracking therapy.Methods Experiments were conducted in vivo and in vitro. In the in vivo experiment, three fiducial markers were implanted percutaneously in each liver of ten rabbits under anesthesia, and the fourth fiducial marker with an external catheter and fixed thin wire was implanted ten days later. After the reference group (the first and the second maker), and the casing group (the first and the fourth marker) were respectively registered and tracked with the Cyberknife, the implantation success rate, registration accuracy, and removal safety of fiducial markers were assessed. The tensile test was performed using liver in vitro by measuring the resistance required to dislodge the spring coil fiducial markers and the fiducial markers without spring coil from liver.Results The intrahepatic catheter implantation and removal of fiducial marker in rabbit liver had a success rate of 100% and no distant migration. The operation-related and postoperative complications were not occurred. All fiducial markers were successfully traced. Compared to the reference group, the casing group had slightly higher translational errors in supero-inferior and antero-posterior directions (Z=-11.77,-4.57,P<0.05), and lower translational errors in left-right direction (Z=-2.52, P<0.05). The dislodgement forces for spring coil fiducial markers was (2.23±0.85)N, significantly different with (0.81±0.13)N for fiducial markers without spring coil (Z=- 2.31, P < 0.05).Conclusions The spiral coil structure provides superior fixation in the punctured needle channel, the thin line limits the distant displacement of the fiducial marker outside the liver, and the catheter establishes a channel for the removal. The general operation is simple and easy. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
