| Deng Fang,Liu Sisi,He Ruimin,Tan Huaxin.Research progress in gold nanoclusters for radiosensitization[J].Chinese Journal of Radiological Medicine and Protection,2022,42(12):1010-1014 |
| Research progress in gold nanoclusters for radiosensitization |
| Received:July 20, 2022 |
| DOI：10.3760/cma.j.cn112271-20220720-00300 |
| KeyWords:Radiotherapy|Radiation sensitizer|Gold nanoclusters |
| FundProject:国家自然科学基金(31800846) |
| Author Name | Affiliation | E-mail | | Deng Fang | Department of Pathology, First Affiliated Hospital of University of South China, Hengyang 421000, China | | | Liu Sisi | Department of Biochemistry and Molecular Biology, School of Basic Medicine, Hengyang Medical School, University of South China, Hengyang 421000, China | | | He Ruimin | Department of Radiotherapy, Second Affiliated Hospital of University of South China, Hengyang 421000, China | | | Tan Huaxin | Department of Biochemistry and Molecular Biology, School of Basic Medicine, Hengyang Medical School, University of South China, Hengyang 421000, China | huaxintan@usc.edu.cn |
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| Abstract:: |
| Radiotherapy still fails to achieve satisfactory efficacy in the treatment of malignant tumors, and applying radiotherapy sensitizers is an effective method to improve the efficacy of radiotherapy. Gold nanomaterials can effectively increase the sensitivity of tumor cells to radiotherapy due to their high atomic numbers. Gold nanoclusters have more excellent radiobiological and radiophysical properties due to their smaller size. This paper reviews the special radiobiological and radiophysical properties of gold nanoclusters and describes in detail their sensitizing effects in external radiation radiotherapy, radionuclide therapy, and X-ray induced photodynamic therapy. |
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