| Huang Taiming,Zhong Jiajian,Guan Qi,Qiu Minmin,Luo Ning,Deng Yongjin.A markerless beam's eye view tumor tracking algorithm based on VoxelMorph-a learning-based unsupervised registration framework for images with missing data[J].Chinese Journal of Radiological Medicine and Protection,2022,42(12):958-965 |
| A markerless beam's eye view tumor tracking algorithm based on VoxelMorph-a learning-based unsupervised registration framework for images with missing data |
| Received:June 28, 2022 |
| DOI：10.3760/cma.j.cn112271-20220628-00272 |
| KeyWords:Makerless tumor tracking|EPID|Voxelmorph|Nonrigid registration|MLC occlusion |
| FundProject: |
| Author Name | Affiliation | E-mail | | Huang Taiming | Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | | | Zhong Jiajian | Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | | | Guan Qi | Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | | | Qiu Minmin | Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | | | Luo Ning | Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | | | Deng Yongjin | Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | dengyj27@mail.sysu.edu.cn |
|
| Hits: 1142 |
| Download times: 382 |
| Abstract:: |
| Objective To propose a machine learning-based markerless beam's eye view (BEV) tumor tracking algorithm that can be applied to low-quality megavolt (MV) images with multileaf collimator (MLC)-induced occlusion and non-rigid deformation.Methods This study processed the registration of MV images using the window template matching method and end-to-end unsupervised network Voxelmorph and verified the accuracy of the tumor tracking algorithm using dynamic chest models. Phantom QA plans were executed after the treatment offset was manually set on the accelerator, and 682 electronic portal imaging device (EPID) images obtained during the treatment were collected as fixed images. Moreover, the digitally reconstructed radiography (DRR) images corresponding to the portal angles in the planning system were collected as floating images for the study of target volume tracking. In addition, 533 pairs of EPID and DRR images of 21 lung tumor patients treated with radiotherapy were collected to conduct the study of tumor tracking and provide quantitative result of changes in tumor locations during the treatment. Image similarity was used for third-party validation of the algorithm.Results The algorithm could process images with different degrees (10%-80%) of data missing and performed well in non-rigid registration of images with data missing. As shown by the phantom verification, 86.8% and 80% of the tracking errors were less than 3 mm and less than 2 mm, respectively, and the normalized mutual information (NMI) varied from 1.18 ± 0.02 to 1.20 ± 0.02 after registration (t = -6.78, P = 0.001). The tumor motion of the clinical cases was dominated by translation, with an average displacement of 3.78 mm and a maximum displacement of 7.46 mm. The registration result of the cases showed the presence of non-rigid deformations, and the corresponding NMI varied from 1.21 ± 0.03 before registration to 1.22 ± 0.03 after registration (t = -2.91, P = 0.001).Conclusions The tumor tracking algorithm proposed in this study has reliable tracking accuracy and high robustness and can be used for non-invasive and real-time tumor tracking requiring no additional equipment and radiation dose. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
