| Ni Yin,Hu Xiaoyan,Hu Lanping,Luo Nana,Qiu Dasheng.Radiation protection effect of furosemide intervention on 18F-FDG PET/CT imaging[J].Chinese Journal of Radiological Medicine and Protection,2022,42(12):980-983 |
| Radiation protection effect of furosemide intervention on 18F-FDG PET/CT imaging |
| Received:March 09, 2022 |
| DOI：10.3760/cma.j.cn112271-20220309-00089 |
| KeyWords:18F-2-deoxy-D-glucose|Positron emission tomography/computed tomography Furosemide|Peripheral dose equivalence rate |
| FundProject: |
| Author Name | Affiliation | E-mail | | Ni Yin | Departmen of Nuclear Medicine, Hubei Tumor Hospital, Wuhan 430079, China | | | Hu Xiaoyan | Departmen of Nuclear Medicine, Hubei Tumor Hospital, Wuhan 430079, China | | | Hu Lanping | Departmen of Nuclear Medicine, Hubei Tumor Hospital, Wuhan 430079, China | | | Luo Nana | Departmen of Nuclear Medicine, Hubei Tumor Hospital, Wuhan 430079, China | | | Qiu Dasheng | Departmen of Nuclear Medicine, Hubei Tumor Hospital, Wuhan 430079, China | hbpetct@163.com |
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| Abstract:: |
| Objective To investigate the radiation protection effect of furosemide intervention on 18F-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography(PET/CT)imaging.Methods A total of 146 patients were randomly divided into two groups, with test group of 74 patients and control group of 72. The test group was administrated orally with furosemide of 40 mg for each one before injection, while the normal control group did not undergo special treatment. 60 and 120 min after 18F-FDG injection, the horizontal measurement of ambient dose equivalent rates was carried out at 0.5 m from the front of both chest and abdomen respectively.Results For the test group, the ambient dose equivalent rates were measured to be (30.80±8.61) and (41.38±11.06) μSv/h 60 min after injection of 18F-FDG whereas (18.26±4.85) and (24.66±6.50)μSv/h 120 min after injection, respectively, both lower than in the control group and with statistically significant difference between the both (t =15.36,13.13,18.73,17.29, P<0.05). No significant difference was found between mediastinal SUVmax and liver SUVmax in the experimental group and control group (P>0.05). Multivariate ANOVA showed that body surface area was a major factor influencing ambient dose equivalent rate regardless of furosemide injection(t=-13.52,2.96, P<0.05), and no obvious effects of age and sex on ambient dose equivalence rate were found.Conclusions Furosemide intervention can promote urination, effectively reduce the internal radiation exposure of the examinated patietns in the premise of not affecting the image quality, and therefore provide a better radiation protection effect. |
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