| Zhuo Yanhong,Wang Youjia,Chen Limin,Zheng Chunnuan,Chen Huiqin,Li Yimin,Jiang Pin,Wang Junjie,Li Yongbin,Huang Jianli.Safety and efficacy of nimotuzumab combined with IMRT radiotherapy in the treatment of elderly patients with locally advanced cervical cancer[J].Chinese Journal of Radiological Medicine and Protection,2022,42(12):928-934 |
| Safety and efficacy of nimotuzumab combined with IMRT radiotherapy in the treatment of elderly patients with locally advanced cervical cancer |
| Received:September 06, 2022 |
| DOI：10.3760/cma.j.cn112271-20220906-00362 |
| KeyWords:Nimotuzumab|Elderly|Cervical cancer|Concurrent chemoradiotherapy|Safety |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhuo Yanhong | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Wang Youjia | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Chen Limin | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Zheng Chunnuan | Department of Pathology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Chen Huiqin | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Li Yimin | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Jiang Pin | Department of Radiology, Peking University Third Hospital, Beijing 100191, China | | | Wang Junjie | Department of Radiology, Peking University Third Hospital, Beijing 100191, China | | | Li Yongbin | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | | | Huang Jianli | Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China | zzhuangjl@163.com |
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| Abstract:: |
| Objective To investigate the safety and efficacy of nimotuzumab combined with IMRT radiotherapy in the treatment of elderly patients with locally advanced cervical cancer (LACC).Methods A retrospective analysis was conducted for 34 elderly LACC patients treated with nimotuzumab combined with IMRT radiotherapy or concurrent chemoradiotherapy in the Zhangzhou Affiliated Hospital of Fujian Medical University from June 2020 to December 2021. The efficacy and side effects were evaluated one and two years after treatment.Results Median follow-up time was 13.3 months (6.1-24.3 months). A total of 24 cases of complete response (CR) and eight cases of partial response (PR) were achieved after treatment, with an objective response rate (ORR) of 94.1% (32/34). The tumor diameters were (49.56 ± 19.22) mm before treatment and (19.61 ± 14.59) mm after treatment, with a tumor regression rate (TRR) of 59.22%.The 1- and 2- year progression-free survival (PFS) rates were 84.9% and 84.9%, overall survival (OS) rates 91.8% and 87.2%, respectively, disease-free survival (DFS) rates 91.8% and 87.2%, respectively, and the cancer-specific survival (CSS) rates 95.7% and 90.9%, respectively. The main adverse events included radiation enteritis, leukopenia, hypoproteinemia and anemia.Conclusions Nimotuzumab combined with IMRT radiotherapy or concurrent chemoradiotherapy is safe and effective in the treatment of LACC. |
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