| Wu Xun,Liu Ruifeng,Zhang Qiuning,Wang Xiaohu.Research progress in the effects of ionizing radiation on lymphatic vessels[J].Chinese Journal of Radiological Medicine and Protection,2022,42(11):909-913 |
| Research progress in the effects of ionizing radiation on lymphatic vessels |
| Received:July 04, 2022 |
| DOI：10.3760/cma.j.cn112271-20220704-00281 |
| KeyWords:Ionizing radiation Lymphatic vessel Tumor Radiotherapy |
| FundProject:甘肃省科技厅重点研发计划项目(20YF8FA116);兰州市人才创新创业项目(2020-RC-113);中华国际医学交流基金会资助项目(Z-2017-24-2108) |
| Author Name | Affiliation | E-mail | | Wu Xun | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China | | | Liu Ruifeng | Lanzhou Heavy Ion Therapy Center, Heavy Ions Hospital, Lanzhou 730010, China | | | Zhang Qiuning | Lanzhou Heavy Ion Therapy Center, Heavy Ions Hospital, Lanzhou 730010, China | zhangqn@impcas.ac.cn | | Wang Xiaohu | Lanzhou Heavy Ion Therapy Center, Heavy Ions Hospital, Lanzhou 730010, China | |
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| Abstract:: |
| Ionizing radiation can induce the death of lymphatic endothelial cells, leading to structural damage, dysfunction, and reduction of lymphatic vessels, which poses a negative impact on radiotherapy. However, it can also induce tumor cells and tumor-infiltrated immune cells to secrete various cytokines and promote tumor-associated lymphangiogenesis, which favors anti-tumor therapy and improve anti-tumor immunity. Studying the changes in lymphatic vessels after ionizing radiation may be a way to explore the synergistic anti-tumor effects of radiotherapy and immunotherapy. This review summarized the morphological changes in lymphatics after ionizing radiation, the molecular mechanisms for the effects of ionizing radiation on lymphatic vessels, and the clinical value of lymphatic changes after ionizing radiation, aiming to provide ideas for the study of the effects of ionizing radiation on lymphatic vessels. |
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