| Wu Qing,Dong Baiqiang,Jin Jianan,Hang Qingqing,Liu Xiaohui,Xu Yujin,Chen Ming.Comparison of the efficacy of stereotactic body radiotherapy and surgery for intrapulmonary recurrence patients after non-small cell lung cancer surgery[J].Chinese Journal of Radiological Medicine and Protection,2022,42(11):857-864 |
| Comparison of the efficacy of stereotactic body radiotherapy and surgery for intrapulmonary recurrence patients after non-small cell lung cancer surgery |
| Received:July 02, 2022 |
| DOI：10.3760/cma.j.cn112271-20220702-00277 |
| KeyWords:Non-small cell lung cancer Stereotactic body radiation therapy Surgical treatment Intrapulmonary recurrence |
| FundProject:浙江省医药卫生科技项目(2020KY079);北京希思科领航肿瘤研究项目(Y-2019AZMS-0061);北京科创医学发展基金会项目(KC2021-JX-0186-63) |
| Author Name | Affiliation | E-mail | | Wu Qing | The Second Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou 310053, China | | | Dong Baiqiang | Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China | | | Jin Jianan | Phase I Clinical Trial Ward, Cancer Hospital Affiliated to University of Chinese Academy of Science, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Hang Qingqing | The Second Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou 310053, China | | | Liu Xiaohui | The Second Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou 310053, China | | | Xu Yujin | Department of Chest Radiotherapy, Cancer Hospital Affiliated to University of Chinese Academy of Science, Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Chen Ming | Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China | chenming@sysucc.org.cn |
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| Abstract:: |
| Objective To compare the efficacy of stereotactic body radiotherapy(SBRT) and surgery in treating intrapulmonary recurrence of non-small cell lung cancer (NSCLC) after radical surgery.Methods A retrospective analysis was conducted on NSCLC patients, who underwent radical surgery at the Cancer Hospital Affiliated to University of Chinese Academy of Sciences from November 2012 to December 2018 and then received SBRT or secondary surgery because of postoperative intrapulmonary recurrence. The survival rates of these patients were calculated using the Kaplan-Meier method. The comparison between the two groups was made using the Log-rank method, and the univariate and multivariate analysis was made using the Cox regression method.Results Among 62 eligible patients, 33 received SBRT and 29 received secondary surgery, and they were divided into the SBRT group and the surgery group accordingly. For the SBRT and surgery groups, the median follow-up time was 45.8 months and 37.4 months, the 3-year locoregional control rate (LRCR) 79.8% and 90.2%, respectively (P ＞ 0.05), the progression-free-survival (PFS) 58.5% and 42.3%, respectively (P ＞0.05), and the overall survival (OS) 78.0% and 85.5%, respectively (P ＞0.05). The multivariate analysis suggested that treatment method, Charlson comorbidity index (CCI), and adjuvant drug therapy were independent prognostic factors for PFS (P = 0.027, 0.013, 0.001).Conclusions The efficacy of SBRT and surgery is comparable for patients with intrapulmonary recurrence of NSCLC after radical surgery. |
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