| Liu Huimeng,Wang Meiyu,Chen Guangrui,Zhou Huiyu,Yuan Yong,Meng Zhiyun,Gu Ruolan,Gan Hui,Wu Zhuona,Dou Guifang.Effects of radon exposure on lung function and metal balance in mice[J].Chinese Journal of Radiological Medicine and Protection,2022,42(11):845-850 |
| Effects of radon exposure on lung function and metal balance in mice |
| Received:August 18, 2022 |
| DOI：10.3760/cma.j.cn112271-20220818-00335 |
| KeyWords:Radon Radon Progeny Trace elements Heavy metal |
| FundProject: |
| Author Name | Affiliation | E-mail | | Liu Huimeng | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Wang Meiyu | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Chen Guangrui | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Zhou Huiyu | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Yuan Yong | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Meng Zhiyun | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Gu Ruolan | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Gan Hui | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Wu Zhuona | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | | | Dou Guifang | Anti-Radiation Drug Research Laboratory, Institute of Radiation Medicine, Academy of Military Medicine, Academy of Military Sciences, Beijing 100850, China | dougf@bmi.ac.cn |
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| Abstract:: |
| Objective To explore the disturbance of metal element balance in mice after exposure to radon.Methods Mice were randomly divided into control group, radon exposure of 30 WLM group, 60 WLM group and 120 WLM groups, with 10 mice in each group. After radon exposure with the cumulative dose, the lung function of mice was detected by a non-invasive pulmonary function testing instrument. Mice blood was taken from eyeballs. The lungs, heart, liver, kidney and spleen were also collected. HE staining was used to observe the pathological changes of lung tissue. Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect the content of metal elements, including essential trace elements in the body: chromium (Cr), molybdenum (Mo), cobalt (Co), selenium (Se), copper (Cu), zinc (Zn), manganese (Mn), nickel (Ni), and potentially toxic elements: arsenic (As), tin (Sn), lead (Pb), aluminum (Al), mercury (Hg), cadmium (Cd), and silver (Ag).Results Compared with the control group, lung ventilation function of the radon-exposed mice was decreased, alveolar structure was destroyed, and the contents of pulmonary metal elements Cr, Al, Pb, Sn(F=0.34, 0.66, 3.14, 1.16, P＜0.05) and essential trace elements Mn, Cr, Zn, and Mo in the blood were decreased(F=0.65, 1.44, 0.97, 2.08, P＜0.05), while the elements of Cu, Mo, Se and As in the lungs were increased(F=1.31, 1.26, 0.81, 2.04, P＜0.05), and the element contents in other tissues also fluctuated.Conclusions Inhalation of a certain cumulative dose of radon can reduce the lung ventilation function of mice and induce lung inflammation, as well reduce the content of essential trace elements in the lung and blood so that the content of metal elements in the body fluctuates. |
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