| Zhang Jun,Zhang Yongsheng,Cao Zhifei.Research progress on the mechanism of cell pyroptosis signaling pathways in radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2022,42(10):817-822 |
| Research progress on the mechanism of cell pyroptosis signaling pathways in radiation injury |
| Received:May 27, 2022 |
| DOI：10.3760/cma.j.cn112271-20220527-00226 |
| KeyWords:Pyroptosis Radiotherapy Radiation injury Ionizing radiation Gasdermin family |
| FundProject:江苏省卫生健康委医学科研项目(H2019071);苏州大学附属第二医院核技术医学应用重点人才项目(XKTJ-HRC2021002) |
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| Abstract:: |
| Pyroptosis is an inflammatory programmed cell death. Unlike apoptosis, pyroptosis is always accompanied by inflammation. It has been found that cell pyroptosis is closely related to the occurrence and development of many diseases. Pyroptosis also plays an important role in radiation injury caused by radiotherapy. Ionizing radiation breaks DNA in cells and induces oxygen free radicals, which are good inducers of pyroptosis. Therefore, this paper reviewed the research progress on the mechanism of cell pyroptosis in radiation injury from the perspective of relative signaling pathways, in order to provide new ideas for weakening or blocking radiation injury. |
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