| Li Junwei,Luo Hui,Hu Yongqiang,Li Shaobei,Sheng Chengyang.Efficacy of low dose whole-lung irradiation for the treatment of moderate to severe COVID-19 pneumonia: Meta-analysis[J].Chinese Journal of Radiological Medicine and Protection,2022,42(10):765-770 |
| Efficacy of low dose whole-lung irradiation for the treatment of moderate to severe COVID-19 pneumonia: Meta-analysis |
| Received:June 20, 2022 |
| DOI：10.3760/cma.j.cn112271-20220620-00257 |
| KeyWords:Coronavirus disease-19 pneumonia Low dose Whole lung irradiation Treatment efficacy Meta-analysis |
| FundProject:河南省科技开放合作项目(18200003597) |
| Author Name | Affiliation | | Li Junwei | Department of Radiation Oncology, Renmin Hospital of Puyang, Puyang 457000, China | | Luo Hui | Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou 450008, China | | Hu Yongqiang | Department of Radiation Oncology, Renmin Hospital of Puyang, Puyang 457000, China | | Li Shaobei | Department of Oncology, Central Hospital of Qingfeng County, Qingfeng 457300, China | | Sheng Chengyang | Department of Radiation Oncology, Renmin Hospital of Puyang, Puyang 457000, China |
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| Abstract:: |
| Objective To systematically evaluate the efficacy of low dose whole-lung irradiation in COVID-19 pneumonia based on the present evidence.Methods All literature related to the application of low dose whole-lung irradiation in COVID-19 pneumonia were retrieved from Pubmed, Embase, the Cochrane Library, Web of Science, Google scholar, Scoupus, CNKI, Wanfang database, VIP database until May 2022. Two researchers independently screened the literature. For the literature that met the inclusion criteria, both data extraction and literature quality evaluation were blinded. Revman 5.3 software was used for statistical analysis.Results A total of 5 controlled clinical trials involving 194 patients met the inclusion criteria. No statistically significant differences were detected in the low dose whole-lung irradiation group compared with the best supportive care group for clinical recovery rates, intubation rates, radiographic improvement rates and 28 d-overall survival.Conclusions In patients of COVID-19 pneumonia, low dose whole-lung irradiation conferred no significant benefit to clinical outcomes. Currently, the routine use of low dose whole-lung irradiation for the treatment of moderate to severe COVID-19 pneumonia is not recommended. |
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