| Lu Xiaoxu,Wang Junjie,Sun Xueming,Huang Rong,Wu Hui.Clinical value of Ki-67 and human epidermal growth factor receptor 2 in stage Ⅲ-ⅣA salivary duct carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2022,42(10):753-758 |
| Clinical value of Ki-67 and human epidermal growth factor receptor 2 in stage Ⅲ-ⅣA salivary duct carcinoma |
| Received:July 15, 2022 |
| DOI：10.3760/cma.j.cn112271-20220715-00293 |
| KeyWords:Ki-67 Human epidermal growth factor receptor 2 Salivary duct carcinoma Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | Lu Xiaoxu | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Hennan Cancer Hospital, Zhengzhou 450008, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Sun Xueming | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Hennan Cancer Hospital, Zhengzhou 450008, China | | | Huang Rong | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Hennan Cancer Hospital, Zhengzhou 450008, China | | | Wu Hui | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Hennan Cancer Hospital, Zhengzhou 450008, China | wuhui7008@126.com |
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| Abstract:: |
| Objective To explore the clinical value of Ki-67 and human epidermal growth factor receptor 2 (HER-2) in salivary duct carcinoma in stage Ⅲ-ⅣA.Methods The data of 52 cases of locally advanced salivary duct carcinoma(SDC) diagnosed from January 2012 to December 2020 were retrospectively analyzed. All patients underwent radical surgery and postoperative radiotherapy. Among them, 15.4% of patients had local recurrence, 28.8% had distant metastasis, 17.3% had regional recurrence with distant metastasis. The relationship between clinical features, pathological features such as Ki-67 and HER-2 and prognosis such as local recurrence and distant metastasis was analyzed.Results The average follow-up time was 37.6 months. The 1- and 2-year local recurrence free survival, distant metastasis free survival, progression free survival were 86.5%, 73.1%, 65.4% and 67.3%, 55.8%, 46.2% respectively. The 3-year progression free survival rate was 33.3%. Comparison between groups showed that age ≥ 65 years old, T stage, TNM stage, vascular tumor thrombus, radiotherapy dose <60 Gy, Ki-67 positive index and HER-2 positive were related to the prognosis of different stages. In multivariate analysis, only age, Ki-67 positive index ≥ 60% and HER-2 protein (3+) were independent poor prognostic factors for locally advanced SDC (t =5.16,9.84,8.23, P<0.05).Conclusions In stage Ⅲ-ⅣA SDC, only radical surgery and postoperative radiotherapy have a high rate of distant metastasis. Ki-67 positive index and HER-2 positive are independent adverse prognostic factors. |
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