| Dong Shuai,Liang Haisheng,Chang Lei,et al.Roles of STAT3 in radiation response, tumor progression and tissue repair[J].Chinese Journal of Radiological Medicine and Protection,2022,42(9):722-726 |
| Roles of STAT3 in radiation response, tumor progression and tissue repair |
| Received:June 08, 2022 |
| DOI：10.3760/cma.j.cn112271-20220608-00246 |
| KeyWords:STAT3 Ionizing radiation Tumor progression Tumor microenvironment Tissue reparation |
| FundProject:国家自然科学基金(31971165,82192883,82173465);霍英东基金会青年基金(171017);江苏省科技计划-面上项目(KB20191422);苏州市姑苏创新创业领军人才计划(ZXL2022454) |
| Author Name | Affiliation | E-mail | | Dong Shuai | State Key Laboratory of Radiation Medicine and Radiation Protection, Soochow University, Co-Innovation Center for Radiation Medicine of Jiangsu University, Suzhou 215123, China | | | Liang Haisheng | State Key Laboratory of Radiation Medicine and Radiation Protection, Soochow University, Co-Innovation Center for Radiation Medicine of Jiangsu University, Suzhou 215123, China | | | Chang Lei | State Key Laboratory of Radiation Medicine and Radiation Protection, Soochow University, Co-Innovation Center for Radiation Medicine of Jiangsu University, Suzhou 215123, China | | | Zhang Peng | Second Affiliated Hospital of Soochow University, Orthopedics/Health Management Center, Suzhou 215123, China | 57994891@qq.com |
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| Abstract:: |
| Signal transducer and activator of transcription (STAT) is a family of cytoplasmic transcription factors including seven proteins of STAT-1,-2,-3,-4,-5A,-5B and-6.The genes encoding the STAT family are located on are located on chromosome 2(STAT1 and STAT4),chromosome 12(STAT2 and STAT6) and chromosome 17(STAT3,STAT5A and STAT5B).Among these seven proteins,STAT3 and STAT5 have the strongest correlation with tumor progression,and ionizing radiation can affect STAT3 level.Continuous activation of STAT3 can regulate a variety of functions,including cell proliferation,cell cycle progression,apoptosis,angiogenesis and immune escape.STAT3 is highly complex in its biological function and activator action.Therefore,it is of great significance to further study the biological function and signaling pathway of STAT3. |
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