| Zhao Dan,Wan Meng,Liu Weixin,Xu Xiaolong,Zheng Baomin,Xiao Shaowen,Gao Shunyu,Zhang Bin,Wang Weihu,Sun Yan.Failure patterns and outcomes after induction chemotherapy followed by radical radiotherapy in patients with locally advanced hypopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2022,42(5):348-354 |
| Failure patterns and outcomes after induction chemotherapy followed by radical radiotherapy in patients with locally advanced hypopharyngeal carcinoma |
| Received:January 16, 2022 |
| DOI：10.3760/cma.j.cn112271-20220116-00020 |
| KeyWords:Chemotherapy Hypopharyngeal neoplasms Prognosis Radiotherapy Recurrence |
| FundProject:国家自然科学基金(82073333);北京市科学技术委员会首都临床特色应用研究基地(Z181100001718192) |
| Author Name | Affiliation | E-mail | | Zhao Dan | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Wan Meng | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Liu Weixin | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Xu Xiaolong | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Zheng Baomin | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Xiao Shaowen | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Gao Shunyu | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Zhang Bin | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Head and Neck Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Wang Weihu | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Sun Yan | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | lisaysun@139.com |
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| Abstract:: |
| Objective To retrospectively analyze the failure patterns and outcomes of patients with locally advanced hypopharyngeal squamous cell carcinoma (HPSCC) after undergoing induction chemotherapy (IC) followed by definitive radiotherapy.Methods For patients with locally advanced HPSCC who were treated with IC and definitive radiotherapy from August 2008 to December 2019, their data were collected from the medical records system, and their clinical characteristics, failure patterns, and survival were retrospectively analyzed.Results A total of 116 eligible patient with squamous cell carcinoma were included in this study. with a median age of 59 (39-79), and 3, 3, 60, and 50 of them had stage Ⅱ, Ⅲ, ⅣA, and ⅣB HPSCC, respectively. Among these patients, 81 received 1~2 cycles of IC, and 35 received 3-4 cycles of IC. After treatment with IC, 54, 13, and 49 patients received concurrent chemoradiotherapy, radiotherapy combined with targeted therapy, and radiotherapy alone, respectively. The median follow-up was 34.6 months (95%CI: 28.7-40.5 months). The 3-year local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), metastasis-free survival (MFS), progression-free survival (PFS), and overall survival (OS) of all the patients were 63.5%, 82.8%, 75.2%, 47.3%, and 43.1%, respectively. Median PFS and OS were 26.1 and 28.0 months, respectively. Treatment failure was reported in 59 patients, of whom 22, 5, 12, 10, 3, 6 and 1 experienced local, regional, distant only, local-regional, regional-distant, local-distant, and local-regional-distant failure, respectively. The objective response rate (CR+PR) of patients after IC was 55.2% (64/116). The LRFS, RRFS, PFS, and OS of IC responders (CR+PR) were better than those of IC non-responders (SD+PD) (χ2 = 12.52, 5.16, 13.19, 11.72, allP<0.05).Conclusions IC combined with radical radiotherapy has efficacy to a certain extent in the treatment of locally advanced HPSCC, and locoregional recurrence predominates the failure patterns. The prognosis of IC responders is significantly better than that of IC non-responders. |
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