| Su Yinping,Sun Zhijuan,Fan Fang,et al.A preliminary study on the probability of causation of male breast cancer for occupational radiation workers[J].Chinese Journal of Radiological Medicine and Protection,2022,42(3):215-218 |
| A preliminary study on the probability of causation of male breast cancer for occupational radiation workers |
| Received:September 18, 2021 |
| DOI：10.3760/cma.j.cn112271-20210918-00384 |
| KeyWords:Male breast cancer Ionizing radiation Occupational radiogenic neoplasms Probability of causation |
| FundProject: |
| Author Name | Affiliation | E-mail | | Su Yinping | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Sun Zhijuan | Thoracic Surgery Department, University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China | | | Fan Fang | Yunnan Center for Disease Control and Prevention, Kunming 650034, China | | | Sun Quanfu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | sunquanfu@nirp.chinacdc.cn |
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| Abstract:: |
| Objective To explore the probability of causation method ology of male breast cancer and to provide theoretical basis for the diagnosis of occupational radiogenic male breast cancer in China. Methods Using the male excess relative risk model (EAR) fitted from the Japanese atomic bomb survivors and the female excess absolute risk model (ERR) provided by the Biological Effect of Ionizing Radiation Committee VII (BEIRVII), the breast dose and the probability of causation of the previous case of male breast cancer were calculated. Results The average probability of causation (PC) calculated by male ERR model was 94.6%, and the upper limit of 95% PC was 98.3%. Using female EAR model and female breast cancer incidence, the average PC was 70.3%, and the upper limit of 95% PC was 153.3%. when male breast cancer incidence was used, the average PC was 99.2%.By both methods, the male breast cancer patient could be determined to be caused by occupational radiation exposure. The upper limit of 95% PC calculated by female EAR model and female breast cancer incidence was higher than that by male ERR model.The uncertainty of probability of causation for female EAR model still need further research. Occupational radiogenic male breast was proposed to listed in occupational radiogenic neoplasms, which will make the list more perfect and scientific and reasonable to meet potential claims. |
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