| Zhong Yiwei,Lyu Xiaoming,Shi Yan,Huang Mingwei,Zheng Lei,Liu Shuming,Guo Chuanbin,Zhang Jianguo.Target and dose design of 125I seed brachytherapy for treatment of pediatric borderline tumor in head neck region[J].Chinese Journal of Radiological Medicine and Protection,2022,42(2):110-114 |
| Target and dose design of 125I seed brachytherapy for treatment of pediatric borderline tumor in head neck region |
| Received:November 17, 2021 |
| DOI：10.3760/cma.j.cn112271-20211117-00454 |
| KeyWords:Brachytherapy Head and neck borderline tumor Pediatric Dosimetry |
| FundProject:国家自然科学基金（81302387）；广东省职业病防治重点实验室（2017B030314152）；广东省自然科学基金（2019A1515011969）；广东省医学科研基金项目（A2017227，A2019246，A2021209）；广州市科技计划项目（202002030031） |
| Author Name | Affiliation | E-mail | | Zhong Yiwei | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Lyu Xiaoming | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Shi Yan | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Huang Mingwei | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Zheng Lei | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Liu Shuming | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Guo Chuanbin | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | | | Zhang Jianguo | Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China | rszhang@126.com |
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| Abstract:: |
| Objective To summarize and evaluate the target and dose design of 125I seed brachytherapy treatment plan of pediatric borderline tumor in head neck region. Methods Eleven patients underwent definitive 125I brachytherapy or combined with surgery in Peking University Hospital of Stomatology from January 2010 to December 2018 were retrospective analyzed. The target region was set by extending the tumor gross region by 0.5 to 1.0 cm. The prescription dose and activity ranged from 80 to 120 Gy and 18.5 MBq, respectively. The treatments were performed according to the plan under general anesthesia. Response and toxic reaction were recorded during follow-up. The preoperative and postoperative dosimetric results were compared; and the local control rate, objective response rate, complete response rate and acute toxic reaction rate were calculated. Results There was no statistically significant difference between preoperative and postoperative dosimetric results (P>0.05). The follow-up time ranged from 33 to 131 months, with a median of 48 months. The local control rate, objective response rate, complete response rate and acute toxic reaction rate were 100%, 100%,71.4% and 81.8%, respectively. Conclusions Under well-designed target and dose, 125I brachytherapy for treatment of pediatric borderline tumor in head neck region would bring ideal therapeutic and toxic outcomes, and could be regarded as a feasible therapy. |
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