| Cao Yangsen,Li Zuofeng,Xu Ning,Guo Xiaojing,Zhang Huojun.Comparisons of dose distributions between IMPT and VMAT for pancreatic cancer[J].Chinese Journal of Radiological Medicine and Protection,2022,42(2):103-109 |
| Comparisons of dose distributions between IMPT and VMAT for pancreatic cancer |
| Received:July 27, 2021 |
| DOI：10.3760/cma.j.cn112271-20210727-00294 |
| KeyWords:Pancreatic cancer Photon Proton Linear accelerator Dose distributions |
| FundProject:上海申康临床"五新"创新研发项目（SHDC2020CR3087B） |
| Author Name | Affiliation | | Cao Yangsen | Department of Radiation Oncology, Changhai Hospital of Naval Medical University, Shanghai 200433, China | | Li Zuofeng | Concord Medical Group, Beijing 100013, China | | Xu Ning | Varian Medical Systems, Beijing 100176, China | | Guo Xiaojing | Department of Health Statistics, Faculty of Medical Services, Naval Medical University, Shanghai 200433, China | | Zhang Huojun | Department of Radiation Oncology, Changhai Hospital of Naval Medical University, Shanghai 200433, China |
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| Abstract:: |
| Objective To compare dose distributions of hypofractionated radiotherapy for pancreatic cancer between IMPT and VMAT. Methods Ten pancreatic cancer cases were included in this retrospective study. Photon (Edge) and proton (Proteus®PLUS) plans were designed by Eclipse and RayStation TPS, respectively. All plans were transferred to MIM system for extraction of parameters, which included Dmin, Dmean and Dmax of PTV, conformity index (CI), new conformity index (nCI), homogeneity index (HI), gradient index (GI), coverage, Dmax and dose-volume of the organs at risk (OARs). Results There was no significant difference in CI between the two groups. The higher PTV Dmin, Dmean, Dmax, D98%, D2%, HI, coverage and the better GI, D2 cm were found in VMAT (t/Z=-4.63-5.32, P<0.05). The lower 10%_PD was found in IMPT (t=-7.47,P<0.05). Regarding the OARs, Dmax of the intestine, stomach, and duodenum and Dmean of the left kidney were similar between two groups without significant difference (P>0.05). The D5 cm3 of the intestine, D10 cm3 of the stomach, D5 cm3 and D10 cm3 of the duodenum, D2/3 of the left kidney, Dmean and D2/3 of the right kidney were lower in IMPT than those in VMAT (t/Z=-8.12——2.60, P<0.05). However, the Dmax and D0.35 cm3 of the spinal cord were higher in IMPT than those in VMAT (t=7.30, 6.77, P<0.05). Conclusions Both of hypofractionated radiotherapy plans of pancreatic cancer designed by VMAT and IMPT could meet clinical needs. No significant difference was found in Dmax of the adjacent gastrointestinal tracts between the two groups. While IMPT had the advantage over VMAT in the case of lower dose-volumes of the gastrointestinal tracts. Nevertheless, less protections of the OARs in front of the tumor volume could be provided by IMPT compared with VMAT. |
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