| Ma Ya,Hou Dianjun,Guo Lei,Song Dan,Zhu Wei,Li Weiguo,Mao Xuesong,Fang Lianying,Wang Zhongwen.Observation on chromosome aberration of peripheral blood lymphocytes in children with vascular diseases after interventional procedure[J].Chinese Journal of Radiological Medicine and Protection,2022,42(2):89-94 |
| Observation on chromosome aberration of peripheral blood lymphocytes in children with vascular diseases after interventional procedure |
| Received:September 22, 2021 |
| DOI：10.3760/cma.j.cn112271-20210922-00387 |
| KeyWords:Ionizing radiation Interventional procedure Children Dicentric chromosome |
| FundProject:国家自然科学基金青年科学基金项目（32100999）；山东省医药卫生科技发展计划项目（202012070680）；山东省自然科学基金项目（ZR2021MH053，ZR2020QC082） |
| Author Name | Affiliation | E-mail | | Ma Ya | China Institute of Atomic Energy, Beijing 102413, China | | | Hou Dianjun | College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250062, China | | | Guo Lei | Qilu Children's Hospital of Shandong University, Jinan 250022, China | | | Song Dan | Qilu Children's Hospital of Shandong University, Jinan 250022, China | | | Zhu Wei | College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250062, China | | | Li Weiguo | College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250062, China | | | Mao Xuesong | College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250062, China | | | Fang Lianying | College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250062, China | | | Wang Zhongwen | China Institute of Atomic Energy, Beijing 102413, China | wangzhw401@163.com |
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| Abstract:: |
| Objective To evaluate the effect of ionizing radiation on chromosome aberration of peripheral blood lymphocytes in children with vascular interventional procedure. Methods The chromosome aberration of peripheral blood lymphocytes was analyzed before and after vascular interventional procedure to assess the effect of low-dose ionizing radiation on chromosomes. Peripheral blood (PB) was collected using heparin as an anticoagulant from 26 patients before and after (within 10 minutes) vascular interventional surgery. Informed consent was obtained from the patients' parents. Results Dicentric + centric ring (dic+r) formation increased significantly (U=647, P<0.01) in peripheral blood lymphocytes of children after interventional operation. No correlation was observed between the rate of dic+r and the cumulative dose (CD), dose area product (DAP), age, body weight, gender and the estimated effective dose E (P>0.05). There was no significant difference in dic+r rate of children between different genders, ages and lesion sites (P>0.05). The dic+r rate after interventional operation exceeded 40×10-3 in 4 of 26 cases with the highest of 95.83×10-3. Conclusions The ionizing radiation during children's vascular interventional procedure might lead to the increase of chromosome aberration of peripheral blood lymphocytes and some children are abnormally sensitive. Great attention should be paid to the justification and radiation protection during interventional procedure for children. |
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