| Wang Dongfang,Qi Xuesong,Wu Lina,et al.MiRNA expressions in peripheral blood plasma of workers in a certain mine[J].Chinese Journal of Radiological Medicine and Protection,2022,42(1):1-6 |
| MiRNA expressions in peripheral blood plasma of workers in a certain mine |
| Received:July 23, 2021 |
| DOI：10.3760/cma.j.cn112271-20210723-00287 |
| KeyWords:Radon Miner Plasma miRNAs |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wang Dongfang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Qi Xuesong | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Wu Lina | National Center for Occupational Safety and Health, Beijing 102300, China | | | Gao Gang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Ruan Jianlei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Piao Chunnan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Jianxiang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | liujianxiang@nirp.chinacdc.cn |
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| Abstract:: |
| Objective To investigate the effect of radon on the expressions of miR-16, miR-106b, miR-449a, let-7g, miR-21, miR-221 and miR-34a in peripheral blood plasma of miners.Methods A total of 46 randomly selected miners worked underground(the underground group)and 38 miners worked aboveground (the control group). MiRNA levels in the underground and control groups were detected by qRT-PCR and their relationship with cumulative effective dose was further analyzed.Results The levels of miR-106b, miR-21, miR-221 in plasma of the study group were significantly higher than those in the control group(Z=-2.32, -2.47, -2.79, P < 0.05), the corresponding Fc values were 1.61, 1.75, 1.30, respectively. The levels of miR-16, miR-449a, let-7g and miR-34a were slightly higher than those in the control group (P>0.05). After controlling of confounding factors such as age, BMI and smoking, the alteration of miR-16, miR-106b, let-7g, miR-21 and miR-221 in plasma of the underground group were positively correlated with the cumulative effective dose(t=2.50, 3.31, 2.60, 2.95, 3.25, P < 0.05). No significant difference was observed in the plasma levels of miR-449a and miR-34a between the two groups (P>0.05).Conclusions miR-106b, miR-21 and miR-221 could be used as potential biomarkers of radon exposure. |
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