| Zhang Yu,Zhang Qingbo,Zhao Chaoyun,Wang Xiaodong,Zhao Ting,Zhu Kai.The application of blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) to the protection of language functional area during postoperative IMRT of cerebral gliomas[J].Chinese Journal of Radiological Medicine and Protection,2021,41(12):931-936 |
| The application of blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) to the protection of language functional area during postoperative IMRT of cerebral gliomas |
| Received:May 14, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.12.009 |
| KeyWords:Blood oxygen level-dependent functional magnetic resonance imaging Language functional area Cerebral gliomas Intensity-modulated radiotherapy |
| FundProject:国家自然科学基金项目（81260373）；宁夏自然科学基金（NZ16272） |
| Author Name | Affiliation | E-mail | | Zhang Yu | Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China | | | Zhang Qingbo | Department of Orthopaedics, Second Affiliated Hospital of Bengbu Medical College, Bengbu 230000, China | | | Zhao Chaoyun | Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China | | | Wang Xiaodong | Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China | xdw80@yeah.net | | Zhao Ting | Department of Radiotherapy, Oncology Hospital, General Hospital of Ningxia Medical University, Yinchuan 750004, China | | | Zhu Kai | Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China | |
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| Abstract:: |
| Objective To investigate the clinical application value of blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) to the protection of language function in patients with unilateral frontal and temporal lobes glioma receiving postoperative intensity modulation radiation therapy (IMRT). Methods A total of 27 patients with unilateral frontal and temporal lobe gliomas were treated with postoperative radiotherapy. The planning CT and BOLD-fMRI were performed before radiotherapy, and the language functional areas were delineated based on the fused images of 3D T1 and CT. IMRT technology was used to develop radiotherapy plans with and without language function area protection, naming conventional and protective radiotherapy plans respectively. The maximum radiation dose (Dmax), average radiation dose (Dmean), target conformal (CI) and dose uniformity (HI) of PTV of the two plans were compared and analyzed to ensure that the protective radiotherapy plan could meet the radiotherapy standard. Then, the Dmax and Dmean of the language function area were compared and analyzed to evaluate whether the Dmax and Dmean of the language function area were decreased in the protective radiotherapy plan. Results There were no significant differences in CI, HI, Dmax and Dmean of PTV between the conventional radiotherapy plan and protective radiotherapy plan (P>0.05). There were statistically significant differences in Dmax and Dmean of Wernicke's and Broca's (healthy side and affected side) between the conventional radiotherapy plan and protective radiotherapy plan (t=3.073-12.707, P<0.05). Dmax and Dmean of Wernicke's and Broca's (healthy side and affected side) were decreased in the protective radiotherapy plan compared with the conventional radiotherapy plan, and the decrease was significant in the healthy side. Conclusions BOLD-fMRI combined with IMRT can not only guarantee the target dose of patients with glioma receiving postoperative radiotherapy, but also reduces the radiation dose to the language function area. Chinese reading task and paragraph comprehension task are the stimulation mode of language function in patients after brain tumor surgery. These tasks are simple and the effect is accurate. |
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