| Shu Yafei,Gu Jing,Hou Min,She Yali,Liu Kai,Duan Yifan.Research progress in miRNAs mediated radiation-induced by stander effect[J].Chinese Journal of Radiological Medicine and Protection,2021,41(11):862-866 |
| Research progress in miRNAs mediated radiation-induced by stander effect |
| Received:June 09, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.11.012 |
| KeyWords:miRNAs Radiation-induced bystander effect Exosome |
| FundProject:甘肃省自然科学基金（21JR1RA262） |
| Author Name | Affiliation | E-mail | | Shu Yafei | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | Gu Jing | Gansu University of Chinese Medicine, Lanzhou 730000, China | 120233234@qq.com | | Hou Min | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | She Yali | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | Liu Kai | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | Duan Yifan | Gansu University of Chinese Medicine, Lanzhou 730000, China | |
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| Abstract:: |
| Radiation-induced bystander effect (RIBE) refers to that irradiated cells release signaling factors and induce responses in nonirradiated cells.In other words, it is the communication between irradiated and nonirradiated cells by intracellular signals. RIBE could influence the efficacy of tumor radiotherapy, but also has potential risk to the normal tissues outside of radiation field. Studies have found that ionizing radiation can induce the alteration of miRNA expression not only in the irradiated cells but also in adjacent nonirradiated tissues, and miRNAs may play an important role in the regulation of signaling pathways between irradiated and nonirradiated bystander cells. This article reviewed the roles of miRNAs in RIBE. |
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