| Wu Ailin,Jiang Xiao,Wu Aidong,Zhu Lei,Yang Yidong,Liu Yunqin,Qian Liting.Impacts of the composition and density of tissue on the dose distribution of implanted 125I seeds[J].Chinese Journal of Radiological Medicine and Protection,2021,41(11):813-817 |
| Impacts of the composition and density of tissue on the dose distribution of implanted 125I seeds |
| Received:March 19, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.11.003 |
| KeyWords:Tissue composition 125I seed Monte Carlo Brachytherapy Dose distribution |
| FundProject:国家自然科学基金（11805198，81671681） |
| Author Name | Affiliation | E-mail | | Wu Ailin | Department of Radiation Oncology, Anhui Provincial Cancer Hospital, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China | | | Jiang Xiao | School of Physics, University of Science and Technology of China, Hefei 230026, China | | | Wu Aidong | Department of Radiation Oncology, Anhui Provincial Cancer Hospital, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China | flkaidongwu@163.com | | Zhu Lei | School of Physics, University of Science and Technology of China, Hefei 230026, China | | | Yang Yidong | School of Physics, University of Science and Technology of China, Hefei 230026, China | | | Liu Yunqin | Department of Radiation Oncology, Anhui Provincial Cancer Hospital, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China | | | Qian Liting | Department of Radiation Oncology, Anhui Provincial Cancer Hospital, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China | |
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| Abstract:: |
| Objective To investigate the impacts of the composition and physical density of tissue on the dose distribution of implanted 125I seeds, in order to provide references for the clinical dose calculation and assessment of implanted radioactive particles. Methods The OncoSeed 6711 physical model of 125I seeds was established using thes of twareegs_brachy and was validated through the calculation of dose rate constant and the radial dose function[g(r)] in water. Then, based on the element composition and physical density of different types of tissue, the g(r) and absorbed dose ratein water, prostate, breast, muscle, and bone were calculated. Results The calculated dose rate constant (0.950 cGy·h-1·U-1) and g(r)in water approached the values in related literature. The absorbed dose in bone was 6.042 times than that in water at a distance of 0.05 cm from the implanted source. The difference between the absorbed doses in breast and water was more than 10% at a distance of less than 1.7 cm from the implanted source. The difference between the absorbed doses in prostate/muscle and water was less than 5% at the same radial location. Conclusions The dose distribution of 125I seeds in some types of human tissue is significantly different from that in water, which should be carefully considered in clinical dose calculation. |
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