| Gao Yu,Lyu Yumin,Sun Quanfu.Hereditary effects of ionizing radiation-a review of human epidemiological studies[J].Chinese Journal of Radiological Medicine and Protection,2021,41(9):716-720 |
| Hereditary effects of ionizing radiation-a review of human epidemiological studies |
| Received:December 01, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.09.014 |
| KeyWords:Ionizing radiation Hereditary effect Birth defect Cancer Human genome |
| FundProject: |
| Author Name | Affiliation | E-mail | | Gao Yu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Lyu Yumin | Department of Toxicology, Henan Institute for Occupational Medicine, Zhengzhou 450052, China | | | Sun Quanfu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | sunquanfu@nirp.chinacdc.cn |
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| Abstract:: |
| Parental exposure to ionizing radiation (IR) can induce mutation in germline that may lead to genome instability, chromosomal aberrations, sex ratio variations, increased cancer susceptibility, and even increased probability of birth defects among their offspring, which substantially increase the burden of hereditary diseases. Up to now, the hereditary effect of IR has been observed in a number of species, but there is lack of evidence in humans. With reference to related studies in China and globally, this article reviews the human epidemiological studies of the hereditary effect of IR and briefly discusses why the hereditary effect of IR is not obvious in humans, so as to provide a reference for future assessment of the hereditary effect of radiation in China. |
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