| Li Xin,Ning Hongxin,Zhao Yazhi,Zhang Yanxin,Li Yiliang,Hou Wenbin.Application of nanoformulations and nanomaterials in the decorporation of radionuclides[J].Chinese Journal of Radiological Medicine and Protection,2021,41(9):711-715 |
| Application of nanoformulations and nanomaterials in the decorporation of radionuclides |
| Received:March 26, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.09.013 |
| KeyWords:Nanometer Decorporation Radionuclides Nuclear radiation |
| FundProject:天津市科技计划项目资助（18ZXXYSY00110）；天津市自然科学基金项目资助（18JCQNJC09500） |
| Author Name | Affiliation | E-mail | | Li Xin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | Ning Hongxin | Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China | | | Zhao Yazhi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | Zhang Yanxin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | Li Yiliang | Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China | liyiliang@irm-cams.ac.cn | | Hou Wenbin | Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China | |
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| Abstract:: |
| Internal contamination of radionuclides in the event of nuclear emergencies can lead to serious harm to human health. The research and development of radionuclide chelating agents and the application of new technologies can reduce the internal damage caused by radionuclides. Compared with traditional preparations, the nano-preparations have the advantages of improving drug dissolution, targeting and positioning drug release, and easily passing through biofilm barrier. In recent years, many scholars have used different nano-preparation forms for different decorporation drugs, including nanoparticles, nano-liposomes, nano-emulsions, etc., to conduct related research in order to achieve better clinical application effects. Nanomaterials with excellent properties have the advantages of high efficiency, rapid adsorption and high biocompatibility, etc., and have been used more and more widely in radionuclide decorporation. In this paper, combined with the relevant literatures at home and abroad, the internal contamination of radionuclides is classified according to nuclide-deposited sites of tissues and organs, and the applications of related nanoformulations and nanomaterials in radionuclide decorporation are introduced in order to provide reference for further research. |
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