Lyu Yumin,Han Lin,Li Jie,Wang Ping,Liu Qingjie.Research progress of chromosome translocation analysis in retrospective biological dose reconstruction[J].Chinese Journal of Radiological Medicine and Protection,2021,41(9):705-710 |
Research progress of chromosome translocation analysis in retrospective biological dose reconstruction |
Received:February 23, 2021 |
DOI:10.3760/cma.j.issn.0254-5098.2021.09.012 |
KeyWords:Ionizing radiation Chromosome translocation Retrospective biodosimetry |
FundProject:河南省科技攻关计划项目(142102310086);河南省医学科技攻关计划项目(LHGJ20190815) |
Author Name | Affiliation | E-mail | Lyu Yumin | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | Han Lin | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | Li Jie | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | Wang Ping | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | Liu Qingjie | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | liuqingjie@nirp.chinacdc.cn |
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Abstract:: |
The application of chromosome translocation to retrospective biodosimetry for A-bomb survivors, the victims previously exposed to nuclear/radiation accident has experienced nearly 40 years of development. Retrospective biodosimetry was internationally paid close attention to radiation workers, exposed atomic veterans and medical exposure subjects, respectively, along with the development of molecular cytogenetic technology such as mFISH and cGH. And the remarkable breakthrough and progress have been made in recent years. This paper reviews the progress of translocation indicator as retrospective biodosimetry for the subjects, in order to provide a reference for retrospective dose estimation based on translocation analysis. |
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