| Han Lei,Hu Xiaoyang,Sun Lei,et al.Effects of tumor treating fields (TTF) arrays on the radiation doses to glioblastoma[J].Chinese Journal of Radiological Medicine and Protection,2021,41(9):685-689 |
| Effects of tumor treating fields (TTF) arrays on the radiation doses to glioblastoma |
| Received:December 09, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.09.008 |
| KeyWords:Tumor treating field Glioblastoma Radiotherapy Dose verification |
| FundProject: |
| Author Name | Affiliation | E-mail | | Han Lei | Department of Radiation Oncology, Shanghai Gamma Hospital, Shanghai 200235, China | | | Hu Xiaoyang | Department of Radiation Oncology, Shanghai Gamma Hospital, Shanghai 200235, China | | | Sun Lei | Cyber knife Center, Affiliated Huashan Hospital of Fudan University, Shanghai 201206, China | | | Zhang Jianying | Department of Radiation Oncology, Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China | | | Xiao Han | Department of Radiation Oncology, Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China | | | Ni Chunxia | Department of Radiation Oncology, Shanghai Gamma Hospital, Shanghai 200235, China | | | Zhou Zhirui | Radiation Oncology Center, Affiliated Huashan Hospital of Fudan University, Shanghai 201107, China | | | Wang Yang | Radiation Oncology Center, Affiliated Huashan Hospital of Fudan University, Shanghai 201107, China | janetcyj@163.com |
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| Abstract:: |
| Objective To preliminarily explore the effects of tumor treating fields (TTF) arrays on the dose distribution in the treatment of Glioblastoma (GBM) using combined radiotherapy and concurrent TTF. Methods EDR2 and MatriXX plate ionization chamber were employed to measure the absorbed doses of tissues at different depths (< 1 mm, 3 mm, 5 mm, 1 cm, 1.5 cm, 3 cm, 5 cm, 10 cm, and 15 cm) in the case that TTF arrays and latex-free foam were attached and not attached on the surface. Then the absorbed doses were calculated, compared, and analyzed. For the volumetric arc therapy (VMAT) of 10 GBM patients, deep dose verification was performed using the Sun Nuclear ArcCheck 3D dose verification system and the D99%, Dmean, and D1% of tumors and OARs were assessed. Results The surface dose increased by 173% in the case that TTF arrays and latex-free foam were attached to the surface compared with the case of the surface with nothing attached. The surface dose increased by 61.7% due to the attachment of low-density latex-free foam. The dose deviation gradually decreased with an increase in the depth and stabilized (about 4%) at a depth of greater than 1.5 cm. As indicated by the VMAT verification result, the D99%, Dmean, and D1% of PTV and CTV decreased by 1.1%-1.2% and the Dmean and D1% of OARs (i.e., brainstem, pituitary gland, optic chiasma, optic nerve, eyeball, and eye crystal) decreased by 0.7%-1.5% in the case that TTF array and latex-free foam were attached on the surface compared with the case the surface with nothing attached. Conclusions The combined radiotherapy and concurrent TTF in the GBM treatment will lead to a slight reduction of the absorbed doses of targets and OARs but a significant increase in the absorbed doses of the scalp. Therefore, it is recommended that the scalp doses should be reduced as far as possible in the design of the radiation treatment plan to reduce the adverse reactions on the scalp of GBM patients. |
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