| Wan Zhijie,Zhao Songyun,Yang Yanyong,et al.Experimental research progress of genetically modified mesenchymal stem cells in the treatment of radiation-induced lung injury[J].Chinese Journal of Radiological Medicine and Protection,2021,41(8):595-601 |
| Experimental research progress of genetically modified mesenchymal stem cells in the treatment of radiation-induced lung injury |
| Received:April 27, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.08.006 |
| KeyWords:Mesenchymal stem cells Genetic modification Radiation-induced lung injury Pulmonary fibrosis Radiation pneumonia |
| FundProject:国家自然科学基金（31670861）；军事医学创新工程课题（18CXZ008） |
| Author Name | Affiliation | E-mail | | Wan Zhijie | Department of Marine Radiation Medicine, Faculty of Naval Medicine, Navy Medical University, Shanghai 200433, China | | | Zhao Songyun | Department of Respiratory and Critical Care Medicine, Changhai Hospital, Naval Medical University, Shanghai 200433, China | | | Yang Yanyong | Department of Marine Radiation Medicine, Faculty of Naval Medicine, Navy Medical University, Shanghai 200433, China | | | Gao Fu | Department of Marine Radiation Medicine, Faculty of Naval Medicine, Navy Medical University, Shanghai 200433, China | gaofusmmu@163.com |
|
| Hits: 3456 |
| Download times: 1589 |
| Abstract:: |
| Radiation-induced lung injury is a common complication of thoracic malignant tumor radiotherapy and severe nuclear accident injury. Currently, there is no effective treatment on this injury. Mesenchymal stem cells (MSCs) are a group of cells with multi-directional differentiation potential and they can protect lung tissue from radiation damage by homing to the injured site and differentiating to the damaged tissues,secreting cytokines and immune regulation. Further,the genetically modifying mesenchymal stem cells have not only the main characteristics of MSCs, but also can efficiently and stably express or knock down a certain of target genes,thereby enhancing or reducing the sensitivity of mesenchymal stem cells to various physiological stimulus and enhancing its therapeutic effect in radiation-induced lung injury, providing new ideas and new strategies for clinical treatment. This paper reviewed the relevant research progress in recent years. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
