| Zhang Ziqi,Long Wei,Xu Wenqing.Role of intestinal stem cells in prevention of radiation-induced intestinal injury[J].Chinese Journal of Radiological Medicine and Protection,2021,41(8):579-586 |
| Role of intestinal stem cells in prevention of radiation-induced intestinal injury |
| Received:January 21, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.08.004 |
| KeyWords:Radiation-induced intestinal injury Intestinal stem cells(ISCs) Intestinal radiation protection Protective agents |
| FundProject:军队后勤研究项目（AEP17J001）；江苏省大学生创新创业训练项目（201910285045Z）。 |
| Author Name | Affiliation | E-mail | | Zhang Ziqi | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China | | | Long Wei | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China | | | Xu Wenqing | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China | xuwenqing@irm-cams.ac.cn |
|
| Hits: 3986 |
| Download times: 1601 |
| Abstract:: |
| At present, there is no effective treatment method of radiation-induced intestinal injury. Clinically, only symptomatic remission therapy can be used. Intestinal stem cells (ISCs) have strong renewal ability, which is an important part of intestinal structure regeneration. To promote the recovery of the number and function of ISCs has been a research hotspot in the treatment of radiation gastrointestinal syndrome. This article introduces the important role of ISCs in the protection of radiation-induced intestinal injury and its clinical application significance from the classification and regulatory mechanism of ISCs, and drugs that regulate the damage, apoptosis and repair of stem cells, so as to provide reference for the future research on the role of intestinal stem cells in radiation protection. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
