| Li Wen,Pan Jiyuan,Li Yi,Ren Hongtao,Wang Yali.Research progress in insufficient fracture after pelvic radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2021,41(6):469-474 |
| Research progress in insufficient fracture after pelvic radiotherapy |
| Received:May 20, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.06.013 |
| KeyWords:Pelvic tumor Radiotherapy Pelvic insufficiency fracture (PIF) |
| FundProject:国家自然科学基金（81141097） |
| Author Name | Affiliation | E-mail | | Li Wen | Department Radiation Oncology of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China | | | Pan Jiyuan | Department Radiation Oncology of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China | | | Li Yi | Department Radiation Oncology of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China | | | Ren Hongtao | Department Radiation Oncology of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China | | | Wang Yali | Department Radiation Oncology of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China | yaliwang72@163.com |
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| Abstract:: |
| Pelvic radiotherapy is a way for treatment of most pelvic tumors, of which the pelvic insufficiency fracture (PIF) is a long-term complication. In this review, research progress of pelvic insufficiency fracture is summarized and discussed. The pathogenesis of PIF is mainly about inhibition of osteoblasts and the risk factors of PIF include old age, postmenopausal status, absence of hormonal replacement therapy, high number of births, smoking history, low body mass index (BMI), concurrent rheumatoid arthritis, concurrent diabetes mellitus, intracavitary brachytherapy of the high dose rate (HDR-ICBT), high dose of radiotherapy, etc. Effective drugs for prevention or treatment of PIF have not been found yet. Delayed diagnosis and misdiagnosis of PIF can cause serious consequences. As a result, further studies are needed to guide clinical work. |
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