| Gao Jie,Wei Dianjun,Liu Jianfeng,Ren Chunhua.Research progress in the molecular mechanisms of histone deacetylase inhibitors for radiosensitization[J].Chinese Journal of Radiological Medicine and Protection,2021,41(6):465-468 |
| Research progress in the molecular mechanisms of histone deacetylase inhibitors for radiosensitization |
| Received:May 07, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.06.012 |
| KeyWords:Radiotherapy Radiosensitization Histone deacetylase inhibitors Selective killing effect |
| FundProject:国家自然科学基金（52073307，81722026）；天津市自然科学基金（18JCQNJC13600） |
| Author Name | Affiliation | E-mail | | Gao Jie | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | | Wei Dianjun | Laboratory Department of Yanda Hospital, Langfang 065201, China | | | Liu Jianfeng | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | | Ren Chunhua | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | renchunhua0815@126.com |
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| Abstract:: |
| Radiotherapy is one of the most commonly used and effective method to treat malignant tumors in clinical practice. However, there are still some limitations including high radiotherapy doses, harmful side effects on normal tissues, and radiation resistance of tumor cells. Therefore, seeking safe and effective radiotherapy sensitizers to improve radiation sensitivity of tumor cells has been focused for a long time. Histone deacetylase inhibitors (HDACIs), as a kind of epigenetic modifiers, can regulate the sensitivity of tumor cells to ionizing radiation and ultraviolet radiation in addition to the inherent anticancer characteristics. This article reviewed the molecular mechanisms of HDACIs in enhancing radiation sensitivity and by selectively killing tumor cells. |
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