| Yang Ye,Hou Yanjie,Xue Shaojun,Liu Huanru,Li Xianfeng.The protective effects of hydrogel implantation in prostate cancer patients for radiotherapy: a Meta-analysis[J].Chinese Journal of Radiological Medicine and Protection,2021,41(6):436-443 |
| The protective effects of hydrogel implantation in prostate cancer patients for radiotherapy: a Meta-analysis |
| Received:December 07, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.06.007 |
| KeyWords:Prostate cancer Hydrogel Radiotherapy Meta-analysis |
| FundProject:安徽省自然科学基金（1908085MA27）；安徽省重点研究与开发计划（1804a09020039） |
| Author Name | Affiliation | E-mail | | Yang Ye | Department of Radiation Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China | | | Hou Yanjie | Department of Radiation Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China | | | Xue Shaojun | Department of Radiation Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China | | | Liu Huanru | Department of Radiation Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China | | | Li Xianfeng | Department of Radiation Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China | lixianfeng-lxf@263.net |
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| Abstract:: |
| Objective To evaluate the protective effects of hydrogel implantation in prostate cancer patients for radiotherapy. Methods A search was performed in PubMed, Web of Science, Cochrane Library, Embase, CNKI and VIP to collect controlled clinical research literature concerning hydrogel implantation in prostate cancer for radiotherapy. The Revman 5.3 software was used to perform meta-analyses of rectal V70, rectal D2 cm3, rectal toxicity effects and bowel symptoms. Results The review included ten controlled clinical trials involving 1 360 patients (690 in the hydrogel group and 670 in the control group). The result of Meta-analysis showed that the rectal V70 and rectal D2 cm3 of prostate cancer patients in the hydrogel group were significantly lower than those in the control group(MD=-4.5,95%CI -7.11 to -1.90,P<0.001;MD=-19.78,95%CI -25.92 to -13.63,P<0.001), early and late G1 rectal toxic effects in the hydrogel group were significantly lower than those in the control group (OR=0.64,95%CI 0.45-0.90,P=0.01;OR=0.28,95%CI 0.13-0.60,P=0.001)and the late bowel quality of life in the hydrogel group was significantly improved compared with the control group(MD=5.13,95%CI 3.29-6.98,P<0.001). However, there were no statistically significant differences in early and late ≥G2 rectal toxic effects(OR=0.46,95%CI 0.17-1.25,P=0.13;OR=0.44,95%CI 0.09-2.17,P=0.31) and the early bowel symptoms(MD=2.30,95%CI -1.31-5.91,P=0.21) between the two groups. Conclusions Hydrogel implantation inprostate cancer for radiotherapy can reduce rectal V70 and rectal D2 cm3, lower the early and late G1 rectal toxic effects, and reduce improve the late bowel symptoms. |
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