| Zhao Yan,Zhu Shuchai,Song Chunyang,Wu Peiwen,Xu Jinrui,Wang Xuan,Yan Ke,Li Shuguang,Shen Wenbin.Prognostic impact of prognostic nutritional index before radiotherapy in clinical stage Ⅲ esophageal cancer patients[J].Chinese Journal of Radiological Medicine and Protection,2021,41(6):426-430 |
| Prognostic impact of prognostic nutritional index before radiotherapy in clinical stage Ⅲ esophageal cancer patients |
| Received:January 09, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.06.005 |
| KeyWords:Esophageal cancer Prognostic nutritional index (PNI) Radiotherapy Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhao Yan | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Zhu Shuchai | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | sczhu1965@163.com | | Song Chunyang | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Wu Peiwen | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Xu Jinrui | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Wang Xuan | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Yan Ke | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Li Shuguang | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Shen Wenbin | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective To study the prognostic impact of prognostic nutritional index (PNI) before radiotherapy in clinical stage Ⅲ esophageal cancer patients. Methods We retrospectively reviewed 125 esophageal cancer patients with clinical stage Ⅲ undergoing definitive radiotherapy in Fourth Hospital of Hebei Medical University from 2013 to 2017. The PNI and nutritional risk index (NRI) were calculated before radiotherapy. The optimal cutoff value of PNI was determined by time-dependent receiver operating characteristics (ROC) at 49.925.The patients were divided into low PNI group(PNI<49.925) and high PNI group (PNI≥49.925).Based on NRI, the patients were divided into normal NRI group (NRI≥100) and abnormal NRI group (NRI<100). Kaplan-Meier method was used to calculate the overall survival (OS) and progression-free survival (PFS) and to perform univariate analysis. The mutlivariate analysis was performed by Cox regression model. Results PNI was positively correlated with hemoglobin (r=0.505,P<0.001) and NRI (r=0.594,P<0.001). The 1-, 3- and 5-year OS rates in the low PNI group were significantly lower than those of the high PNI group (67.5%, 27.3%, 11.4% vs. 85.4%, 45.8%, 27.4%, respectively, χ2=8.569, P<0.05). Moreover, the 1-, 3- and 5-year PFS rates in the low PNI group were obviously higher than those in the high PNI group (59.7%, 23.2%, 4.9% vs. 79.2%, 35.4%, 24.9%, respectively, χ2=6.715,P<0.05). Univariate analysis showed that GTV, radiotherapy dose, chemotherapy, albumin, NRI and PNI were significantly correlated with OS and PFS (OS:χ2=6.822,4.326, 4.474, 13.123, 8.846, 8.569, P<0.05: PFS:χ2=7.869, 4.636, 5.874, 10.911, 8.544, 6.715,P<0.05). Multivariate analysis showed that GTV, radiotherapy dose and PNI were independent prognostic factors for OS (P<0.05). And GTV, radiotherapy dose, chemotherapy and PNI were independent prognostic factors for PFS (P<0.05). Conclusions The PNI before radiotherapy is a significant and independent predictor for survival of clinical stage Ⅲ esophageal cancer patients. Based on simple and inexpensive standard laboratory measurements, PNI could be a promising prognostic biomarker for esophageal cancer patients. |
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