| Xu Bichun,Guo Qi,Qian Jianjun,Xu Yingying,Tian Ye.Advances in bowel delineation and dose-volume constraint in intensity modulated radiation therapy and 3D conformal radiation therapy for pelvic tumors[J].Chinese Journal of Radiological Medicine and Protection,2021,41(4):315-320 |
| Advances in bowel delineation and dose-volume constraint in intensity modulated radiation therapy and 3D conformal radiation therapy for pelvic tumors |
| Received:August 09, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.014 |
| KeyWords:Intensity-modulated radiation therapy Adverse events Pelvic cavity Delineation Dose-volume constraint |
| FundProject:江苏省重点研发计划专项（BL2018657）；江苏省医学创新团队A类项目（CXDT-37） |
| Author Name | Affiliation | E-mail | | Xu Bichun | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou 215004, China | | | Guo Qi | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou 215004, China | | | Qian Jianjun | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou 215004, China | | | Xu Yingying | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou 215004, China | | | Tian Ye | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou 215004, China | dryetian@126.com |
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| Abstract:: |
| Intestinal injury is an important toxic response during radiation therapy of pelvic tumors. With the widespread use of precision radiotherapy techniques such as intensity modulated radiation therapy (IMRT), the dose exposed to normal tissues and organs has been significantly reduced. However, the toxic response of the bowel still limits the increase of the dose to the target volume. Therefore, the protection of important organs at risk (OAR), such as the bowel, becomes more and more important while giving adequate irradiated dose to the target volume. Most current studies used loop to contour bowel. For patients who underwent IMRT, the meaningful dose-volume predictors of grade 2 acute intestinal adverse events using bowel loop (small loop + big bowel) delineation included V45 Gy < 50 cm3, V50 Gy < 13 cm3, and V55 Gy < 3 cm3, and the corresponding predicators using bowel bag delineation were V40 Gy < 170 cm3, V45 Gy < 100 cm3, and V50 Gy < 33 cm3. |
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