| Xiang Jing,Huang Ruixue.Research progress on the mechanism of circRNA regulating radioresistance-related pathways[J].Chinese Journal of Radiological Medicine and Protection,2021,41(4):304-308 |
| Research progress on the mechanism of circRNA regulating radioresistance-related pathways |
| Received:May 14, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.012 |
| KeyWords:CircRNA Radiotherapy resistance Cancer |
| FundProject:国家自然科学基金（U1803124）；湖南省自然科学基金（2019JJ40396） |
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| Abstract:: |
| Radiotherapy is an important means to treat malignant tumors in clinical practice. However, tumor radioresistance not only seriously limits the efficiency of radiotherapy, but also leads to poor prognosis of patients, which may eventually lead to tumor metastasis and recurrence. Circular RNA (circRNA) is a new member of noncoding RNA, which is highly specific, stable and conservative. This paper reviewed with the effect of circRNA on the signal pathways related to radiotherapy resistance by analyzing the perspective of DNA damage repair pathway, EMT (epithelial mesenchymal transition) process, Wnt pathway, tumor stem cells and other pathways, and sorted out the mechanism of circRNA in tumor cell resistance to radiotherapy, which may provide valuable clues for further study of circRNA. |
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