| Xing Haiqun,Zhu Wenjia,Dong Chengyan,Wang Jingnan,Shi Ximin,Wu Meiqi,Yao Shaobo,Li Fang,Huo Li.Radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET in patients with hepatobiliary tumor[J].Chinese Journal of Radiological Medicine and Protection,2021,41(4):293-298 |
| Radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET in patients with hepatobiliary tumor |
| Received:September 23, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.010 |
| KeyWords:68Ga-FAPI-04 PET/CT Hepatobiliary tumor Radiation dosimetry Biodistribution |
| FundProject:国家自然科学基金（U1803124）；湖南省自然科学基金（2019JJ40396） |
| Author Name | Affiliation | E-mail | | Xing Haiqun | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | | | Zhu Wenjia | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | | | Dong Chengyan | GE Healthcare China, Beijing 100176, China | | | Wang Jingnan | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | | | Shi Ximin | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | | | Wu Meiqi | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | | | Yao Shaobo | Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China | | | Li Fang | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | | | Huo Li | Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China | huoli@pumch.cn |
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| Abstract:: |
| Objective To investigate the radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET/CT in patients with hepatobiliary tumor. Methods A total of six patients with hepatic lesions who underwent PET/CT examination in Peking Union Medical College Hospital were enrolled. After intravenous injection of radiotracer 68Ga-FAPI-04 at (170.57 ±14.43) MBq, whole-body imaging were performed at the time points of 3, 10, 15, 20, 30 and 60 min, respectively. Biodistribution pattern was observed. Regions of interest were manually delineated. Radiation dosimetry of all target organs were calculated by Olinda/EXM software. Results The radioactive uptake dissipated gradually in liver whereas it was relatively stable in tumor lesions. The average SUVmax of tumor lesions reached the maximum value (13.87±2.55) at 20 min after injection. The target-to-background ratio increased with time, reaching the maximum value (10.09 ±8.17) at 30 min after injection. The average effective dose in total body was (0.020 ±0.002) mSv/MBq and organ with the highest effective dose was bladder wall at (0.146 ±0.035) mSv/MBq. Conclusions The effective dose in total body of 68Ga-FAPI-04 was similar to that of 18F-FDG. 68Ga-FAPI-04 is expected to be a PET/CT radiotracer for hepatobiliary tumors in consideration of rapid tumor uptake, low accumulation of liver background, and no influence of blood sugar levels. |
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