| Li Minjie,Huang Pingping.Comparison of adverse reactions between hypofractionated radiotherapy and conventional radiotherapy after breast conserving surgery based on body membrane fenestration[J].Chinese Journal of Radiological Medicine and Protection,2021,41(4):271-275 |
| Comparison of adverse reactions between hypofractionated radiotherapy and conventional radiotherapy after breast conserving surgery based on body membrane fenestration |
| Received:October 23, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.006 |
| KeyWords:Hypofractionated radiotherapy Conventional radiotherapy Breast cancer Breast conserving surgery Body membrane |
| FundProject:安徽省自然科学基金面上项目（2008085MA24） |
|
| Hits: 3320 |
| Download times: 1539 |
| Abstract:: |
| Objective To analyze the adverse reactions, cosmetic effects and the improvement in positioning of breast cancer patients who received breast-conserving operation followed by hypofractionated radiotherapy and conventional radiotherapy based on the positioning of body membrane method with windowing method. Methods From January 2019 to April 2020, 75 patients with breast cancer were randomly divided into two groups:hypofractionated radiotherapy (38 cases) administered with 42.4 Gy/16 fractions (2.65 Gy/fraction), and conventional group (37 cases) with 50 Gy/25 fractions (2.0 Gy/fraction). All of them were located by thermoplastic film, and the upper parts of the thermoplastic film were cut along the root of the breast. The adverse reactions, cosmetic effect and follow-up survival of the two groups were observed. Results During the follow-up period, there was no recurrence in the two groups within 8 months. The local control rate and the survival rate of all the patients were both 100%. The total incidence of acute skin reaction in the two groups was 36.84% (14/38) in the hypofractionated group and 67.57% (25/37) in the conventional group (χ2=7.09, P<0.05). The excellent and good rate of cosmetic effect was 89.47% (34/38) in the hypofractionated group and 78.38% (29/37) in the conventional group, but the difference was not statistically significant (P>0.05). There were not statistically differences in the late skin reaction, leucopenia and thrombocytopenia between the two groups (P>0.05). Conclusions Breast-conserving surgery followed by hypofractionated radiotherapy with the positioning of body membrane windowing localization method is feasible and safe. Also, it can significantly reduce the acute radiation skin reactions. But the long-term effects still need to be confirmed by long-term follow-up. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
