| Tao Yin,Zhang Zengpeng,Liu Hongdong,X. George Xu,Pei Xi,Chen Zhi.Assessment of biological dose of proton radiotherapy based on different relative biological effect models[J].Chinese Journal of Radiological Medicine and Protection,2021,41(4):265-270 |
| Assessment of biological dose of proton radiotherapy based on different relative biological effect models |
| Received:November 06, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.005 |
| KeyWords:Monte Carlo Proton Biological dose Linear energy transfer |
| FundProject:安徽省自然科学基金面上项目（2008085MA24） |
| Author Name | Affiliation | E-mail | | Tao Yin | Department of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230027, China | | | Zhang Zengpeng | Department of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230027, China | | | Liu Hongdong | Sun Yat-sen University Cancer Center, Guangzhou 510000, China | | | X. George Xu | Department of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230027, China | | | Pei Xi | Anhui Wisdom Technology Co. Ltd, Hefei 230088, China | | | Chen Zhi | Department of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230027, China | zchen@ustc.edu.cn |
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| Abstract:: |
| Objective To assess proton biological dose with using two kinds of relative biological effect models and to compare them with traditional clinical proton biological dose (Dose1.1). Methods Based on Particle simulation tools(TOPAS), physical dose, LETd and LETt were calculated in water phantom and two anthropomorphic phantoms (brain and prostate tumors) respectively. Then DoseLETd and DoseLETt were calculated according to different relative biological effect models, an RBE was 1.1 in traditional clinical proton biological dose calculation. Three kinds of biological doses were compared in the water phantom. To quantify the differences between three method in anthropomorphic phantoms, three points (D1, D2, D3) were selected according to the physical dose to compare the biological dose. Results DoseLETd and DoseLETt in water phantom showed the same trend with water depth and both of them were higher than Dose1.1 at the end of proton beam range. The maximal difference between DoseLETd and DoseLETt in the anthropomorphic phantoms was 10.08 cGy, where the relative difference was less than 5%. When DoseLETd and DoseLETt were compared with Dose1.1, the maximal differences in brain tumor target were 71.97 cGy and 61.91 cGy respectively, where the relative differences were less than 25%. The maximal differences in prostate tumor target were 25.95 and 19.96 cGy respectively, where the relative differences were less than 12%. However, the differences outside the target were very small, where the maximal differences in brain and prostate tumors were 5.99 cGy and 9.92 cGy respectively, and the relative differences were less than 5%. Conclusions Biological doses calculated by two method are of little difference in both water and anthropomorphic phantoms, however, large differences were observed when they were compared with the traditional clinical proton biological dose especially in the high dose area. |
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