| Yi Junxuan,Wang Rui,Wei Xinfeng,Wang Mingwei,Jin Shunzi.Research progress of RNA m6A modification in malignant tumor and its mechanism of radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2021,41(3):234-240 |
| Research progress of RNA m6A modification in malignant tumor and its mechanism of radiotherapy |
| Received:November 30, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.03.014 |
| KeyWords:N6-methyladenosine modification Writers Erasers Readers Radiation Therapy |
| FundProject:国家自然科学基金面上项目（81872550， 81573085） |
| Author Name | Affiliation | E-mail | | Yi Junxuan | Key Laboratory of Radiobiology, National Health Commission, School of Public Health, Jilin University, Changchun, 130021, China | | | Wang Rui | Key Laboratory of Radiobiology, National Health Commission, School of Public Health, Jilin University, Changchun, 130021, China | | | Wei Xinfeng | Key Laboratory of Radiobiology, National Health Commission, School of Public Health, Jilin University, Changchun, 130021, China | | | Wang Mingwei | Key Laboratory of Radiobiology, National Health Commission, School of Public Health, Jilin University, Changchun, 130021, China | | | Jin Shunzi | Key Laboratory of Radiobiology, National Health Commission, School of Public Health, Jilin University, Changchun, 130021, China | jinsz@jlu.edu.cn |
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| Abstract:: |
| N6-methyladenosine (m6A) is the most abundant RNA base modification in mammals, especially in eukaryotic messenger RNA (mRNA). N6-methyladenosine modification can regulate RNA splicing, translocation, stability and ultimately affect protein synthesis. m6A modification is catalyzed by RNA writers, reduced by erasers and also be recognized by readers. Abnormal changes ofm6A levels are closely related to tumor occurrence and development, including proliferation, growth, invasion and metastasis. In the process of tumor radiotherapy, m6A modification affects the efficacy of radiotherapy by affecting DNA damage, tumor stem cell generation and tumor cell radiation sensitivity. This article reviews the role of m6A-modified epigenetic regulation in malignant tumors and the research progress of its mechanism in tumor radiotherapy, in order to provide new ideas for the development of clinical tumor molecular targeted therapies and radiosensitizers. |
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