| Jiang Ping,Deng Xiuwen,Qu Ang,et al.Feasibility of 3D-printing template-assisted and CT-guided 192Ir interstitial brachytherapy in the treatment of recurrent gynecologic tumors[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):56-61 |
| Feasibility of 3D-printing template-assisted and CT-guided 192Ir interstitial brachytherapy in the treatment of recurrent gynecologic tumors |
| Received:August 27, 2020 Revised:February 24, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.012 |
| KeyWords:3D-printing individual template Gynecologic tumors High dose rate afterloading Interstitial brachytherapy Dosimetric parameters |
| FundProject:国家重点研发计划项目（2019YFB1311300） |
| Author Name | Affiliation | E-mail | | Jiang Ping | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Deng Xiuwen | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Qu Ang | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Jiang Weijuan | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Sun Haitao | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Li Xu | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Dong Junyao | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Zhang Xile | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | junjiewang_edu@sina.cn |
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| Abstract:: |
| Objective To investigate the accuracy and feasibility of 3D-printing individualized template-guided and CT-guided 192Ir interstitial brachytherapy in the central recurrent gynecologic tumors by comparing pre-plan and intraoperative physical dosimetric parameters.Methods This study involved 38 patients with central recurrent gynecologic tumors who underwent 3D printing individual template (3D-PIT)-assisted and CT-guided 192Ir interstitial brachytherapy in the Department of Radiation Oncology of the Peking University Third Hospital from Jan 2018 to Dec 2019.The prescription doses for the target tumor areas were 10-36 Gy to be delivered at 5-6 Gy/fraction for 2-6 fractions.The pre-plan and intraoperative dosimetric parameters were compared, including the minimum prescription doses delivered to 90% and 100% of target volume(D90, D100)and the mean percentage of volume receiving 100% of the prescription doses (V100). Meanwhile, the doses delivered to 2 cm3 (D2 cm3) of organs at risk (bladders, rectums, and colons) were analyzed.The quality parameters of the brachytherapy were studied, including conformity index (CI), homogeneity index (HI), and external index (EI) of the target volume.Perioperative complications were also observed.Results A total of 194 treatments were included.During the treatment, 5-13 (median 6) needles were inserted, with a prescription dose of 5-6 Gy per fraction.There were no statistical differences between pre-plan and intraoperative D90,D100,V100, CI,HI, and EI as well as the D2 cm3 of bladders and colons at risk (P>0.05). In contrast, for the D2 cm3 of rectums, the intraoperative dose was slightly higher than the pre-plan dose, showing a statistical difference (t=-0.335,P=0.027). Conclusions The 3D-PIT-assisted and CT-guided 192Ir interstitial brachytherapy at a high dose rate is accurate and feasible in the treatment of recurrent gynecologic tumors, meeting the pre-plan dose requirement. |
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