| Jiang Ping,Ji Zhe,Jiang Yuliang,et al.Dosimetry evaluation of navigation system-assisted and CT-guided seed implantation in the treatment of recurrent malignant pelvic tumors[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):50-55 |
| Dosimetry evaluation of navigation system-assisted and CT-guided seed implantation in the treatment of recurrent malignant pelvic tumors |
| Received:July 24, 2020 Revised:August 27, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.011 |
| KeyWords:Image navigation system 3D-printing template Radioactive seed implantation Dosimetry Recurrent malignant pelvic tumors |
| FundProject:国家重点研发计划（2019YFB1311300） |
| Author Name | Affiliation | E-mail | | Jiang Ping | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Ji Zhe | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Jiang Yuliang | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Guo Fuxin | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Sun Haitao | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | junjiewang_edu@sina.cn |
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| Abstract:: |
| Objective To explore the accuracy of CT-guided 125I seed implantation assisted by a navigation system and 3D-printing template in the treatment of recurrent malignant pelvic tumors by comparing pre-plan and intraoperative physical dosimetric parameters.Methods This study involved 15 patients with recurrent malignant pelvic tumors who received CT-guided radioactive 125I seed implantation assisted by a navigation system and 3D-printing template in the Peking University Third Hospital from Dec 2018 to Feb 2020.Seven of the patients had cervical cancers, seven had rectal cancers, and one had prostate cancer.The median age was 55 years (34-84 years old). The prescription dose was 100-150 Gy.The pre-plan and post-implant data were compared, including the number of implanted seeds, implantation needle number, and some dosimetric parameters such as the minimum prescription doses delivered to 90% and 100% of target volume(D90, D100), mean percentages of volume receiving 100%, 150%, and 200% of the prescription doses(V100, V150, and V200), conformity index(CI), external index(EI), and homogeneity index(HI)of the target volume.Results The median lesion volume was 29.20 cm3, the median seed number was 54, and the median D90 was 150 Gy.The post-implant V150 was lower than pre-plan V150 (64.1% vs. 67.1%, t=2.937, P=0.011), and the post-implant mean HI was higher than pre-plan HI (32.01% vs. 26.68%, t=-2.950, P=0.011). There were no significant differences in other dosimetric parameters before and after seed implantation.Conclusions With CT-guided radioactive seed implantation assisted by a navigation system and 3D-printing template in the treatment of recurrent malignant pelvic tumors, the actual postoperative dose could meet the preoperative plan requirement, ensuring the accuracy and consistency of the dose delivered. |
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