| Liu Fei,Sun Yunchuan,Xiao Li,et al.Clinical application of 192Ir three-dimensional brachytherapy combined with intensity-modulated radiotherapy in advanced extrahepatic cholangiocarcinoma[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):46-49 |
| Clinical application of 192Ir three-dimensional brachytherapy combined with intensity-modulated radiotherapy in advanced extrahepatic cholangiocarcinoma |
| Received:August 16, 2020 Revised:July 24, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.010 |
| KeyWords:192Ir Three-dimensional brachytherapy Extrahepatic cholangiocarcinoma |
| FundProject:国家重点研发计划（2019YFB1311300）；北京大学第三医院院临床重点项目（BYSYZD2019010） |
| Author Name | Affiliation | E-mail | | Liu Fei | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061000, China | | | Sun Yunchuan | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061000, China | sunyunchuan@163.com | | Xiao Li | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061000, China | | | Bi Jianqiang | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061000, China | |
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| Abstract:: |
| Objective To explore the efficacy and safety of 192Ir three-dimensional brachytherapy combined with intensity-modulated radiotherapy in patients with unresectable advanced obstructive extrahepatic cholangiocarcinoma.Methods A retrospective analysis of the efficacy and safety of 18 patients with unresectable advanced malignant obstructive extrahepatic cholangiocarcinoma admitted to the Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei province from January 2014 to January 2018.All patients were pathologically confirmed and received biliary stent implantation, followed by sequential intensity-modulated radiotherapy and 192Ir three-dimensional brachytherapy.The clinical data of all patients were collected, including gender, age, clinical stage, adverse reactions, brachytherapy dose-volume parameters, changes in bilirubin levels before and after treatment, evaluation of efficacy, local control rate and survival rate.Results All patients successfully completed the treatment.Re-examination was conducted one month after the combined treatment, of the 18 patients, 16 had partial remission (PR) and 2 were stable (SD). Among them, 14 patients had tumor shrinkage after brachytherapy compared with intensity-modulated radiotherapy, and 4 patients showed no significant change. The 6-month local control rate (LC) was 94.4% (17/18). The 1-year survival rate was 55.6% (10/18), and the 2-year survival rate was 38.9% (7/18). Statistical analysis showed that after combined treatment, total bilirubin and direct bilirubin were significantly reduced, and jaundice symptoms were significantly relieved.The adverse reactions of the patient were nausea, vomiting, fever, biliary tract infection, etc.There were no adverse reactions of grade 3 or above.Conclusions 192Ir three-dimensional brachytherapy combined with intensity-modulated radiotherapy in patients with inoperable advanced extrahepatic cholangiocarcinoma has a good local control rate and tolerable adverse reactions, but the impact on long-term survival requires a large sample of controlled studies. |
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