| Sun Haitao,Wang Junjie,Jiang Yuliang,et al.Preoperative dosimetric comparison between non-coplanar and coplanar template-assisted 125I seed implantation for pancreatic cancers[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):42-45 |
| Preoperative dosimetric comparison between non-coplanar and coplanar template-assisted 125I seed implantation for pancreatic cancers |
| Received:May 18, 2020 Revised:May 18, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.009 |
| KeyWords:Radioactive seed implantation Coplanar template Non-coplanar template Dosimetry Pancreatic cancer |
| FundProject: |
| Author Name | Affiliation | E-mail | | Sun Haitao | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | junjiewang_edu@sina.cn | | Jiang Yuliang | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Ji Zhe | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Guo Fuxin | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Chen Yi | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Fan Jinghong | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | |
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| Abstract:: |
| Objective To compare preoperative planning parameters between non-coplanar and coplanar template-assisted radioactive seed implantation in the treatment of pancreatic cancers, in order to guide clinical application.Methods Patients with pancreatic cancers who received external irradiation in the Peking University Third Hospital from Jan 2017 to May 2019 were selected.Their image information was imported into the brachytherapy planning system, and the non-coplanar plan and coplanar plan were designed individually.Each patient's prescription dose was set to 110 Gy, and the activity of the radioactive seeds were 0.4 mCi(1 Ci=3.7×1010Bq), respectively.For the two plans, the dose distribution was optimized and dosimetric parameters were compared, including the implantation needle number, the implanted seed number, the minimum prescription doses delivered to 90% and 100% of the target volume (D90 and D100), mean percentages of volume receiving 100%, 150% and 200% of the prescription doses (V100, V150 and V200), conformity index (CI), external index (EI), and homogeneity index (HI) of the target volume, as well as the doses of 2 cm3 and 5 cm3 (D2 cm3 and D5 cm3) of the surrounding normal organs such as the small intestines, colon, duodenum, stomach, and spinal cord.Results The implantation needle number in the coplanar plan was slightly higher than that in the non-coplanar plan, namely 18.63 vs. 16.45 (t=-3.239, P<0.05). The implanted seed number was equivalent, namely 90.2 vs. 91.01, with no statistical difference (P>0.05). There was no significant difference between D90, D100, V100, V150, V200, CI, EI, and HI in the target area of the two plans (P>0.05). Meanwhile, there was no obvious difference in D2 cm3 and D5 cm3 of normal organs including the small intestines, colon, duodenum, stomach, and spinal cord (P>0.05). Conclusions With both the coplanar plan and the non-coplanar plan, the prescription doses can be achieved and meanwhile, there are very small differences in the doses of normal organs.Given that 3D-printing non-coplanar and coplanar templates have their own characteristics, it is necessary to choose them according to specific situations. |
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