| Gao Ya,Zhang Jie,Liu Shuming,et al.Application of 125I interstitial brachytherapy in the treatment of local advanced parotid adenoid cystic carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):9-13 |
| Application of 125I interstitial brachytherapy in the treatment of local advanced parotid adenoid cystic carcinoma |
| Received:May 25, 2020 Revised:May 25, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.003 |
| KeyWords:Parotid Adenoid cystic carcinoma 125I radioactive seeds Interstitial brachytherapy Local advanced stage |
| FundProject: |
| Author Name | Affiliation | E-mail | | Gao Ya | Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Peking University, National Clinical Research Center for Oral Diseases, National Engineering Laboratory of Dental Digital Medical Technology and Materials, Beijing Key Laboratory of Dental Digital Medicine, Beijing 100081, China | | | Zhang Jie | Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Peking University, National Clinical Research Center for Oral Diseases, National Engineering Laboratory of Dental Digital Medical Technology and Materials, Beijing Key Laboratory of Dental Digital Medicine, Beijing 100081, China | | | Liu Shuming | Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Peking University, National Clinical Research Center for Oral Diseases, National Engineering Laboratory of Dental Digital Medical Technology and Materials, Beijing Key Laboratory of Dental Digital Medicine, Beijing 100081, China | | | Zheng Lei | Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Peking University, National Clinical Research Center for Oral Diseases, National Engineering Laboratory of Dental Digital Medical Technology and Materials, Beijing Key Laboratory of Dental Digital Medicine, Beijing 100081, China | | | Huang Mingwei | Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Peking University, National Clinical Research Center for Oral Diseases, National Engineering Laboratory of Dental Digital Medical Technology and Materials, Beijing Key Laboratory of Dental Digital Medicine, Beijing 100081, China | | | Zhang Jianguo | Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Peking University, National Clinical Research Center for Oral Diseases, National Engineering Laboratory of Dental Digital Medical Technology and Materials, Beijing Key Laboratory of Dental Digital Medicine, Beijing 100081, China | rszhang@126.com |
|
| Hits: 3204 |
| Download times: 1688 |
| Abstract:: |
| Objective To evaluate the efficacy of 125I interstitial brachytherapy in the treatment of local advanced parotid adenoid cystic carcinoma (ACC), and to analyze prognostic factors affecting treatment outcome, in order to provide references for the treatment of local advanced parotid adenoid cystic carcinoma.Methods Patients with histology-confirmed ACC of the parotid who received 125I interstitial brachytherapy in Peking University Hospital of Stomatology between Aug 2007 and Jan 2018 were included.Prognostic factors affecting overall survival (OS), progression-free survival (PFS), and local control rate (LCR) were analyzed.Meanwhile, distant metastases as well as acute and long-term radiological toxicities were described.Results A total of 16 patients (11 females, mean age 55.4 years) of stage cT4bN0M0 who received definitive 125I interstitial brachytherapy were included.The median follow-up period was 41.5 months (8-104 months),and the 1-, 3- and 5-year OS were 86.7%, 72% and 54%, respectively.Five patients suffered from local recurrence, the 1-, 3- and 5-year LCR were 93.7%, 80% and 68.7%, respectively, and the 1-, 3- and 5-year PFS were 74%, 53%, and 18.9%, respectively.Nine cases developed distant metastases.Among them, intracranial and pulmonary metastases took place the most frequently and six patients who had skull base invasion developed multi-organ metastases.An encased carotid artery was an independent prognostic factor for distant metastases (HR=12, P=0.045). Severe radiological toxicities were observed in eight patients (8/16, 50%), including radio-dermatitis, hearing loss, progressive trismus, and eye toxicities.Conclusions The 5-year LCR in patients treated with definitive 125I interstitial brachytherapy for local advanced ACC of the parotid was 68.7%, and skull base invasion and an encased carotid artery were independent adverse prognostic factors of bad prognosis and multi-organ metastases. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
