| Deng Xiuwen,Ji Zhe,Jiang Yuliang,et al.Dosimetric evaluation of 125I seed implantation assisted by an optical navigation system and a 3D-printing template in the treatment of recurrent head and neck cancers[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):3-8 |
| Dosimetric evaluation of 125I seed implantation assisted by an optical navigation system and a 3D-printing template in the treatment of recurrent head and neck cancers |
| Received:June 02, 2020 Revised:June 02, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.002 |
| KeyWords:Optical navigation system 3D-printing template Radioactive seed implantation Dosimetry Recurrent head and neck cancer |
| FundProject:国家科技部重点研发项目（2019YFB1311300） |
| Author Name | Affiliation | E-mail | | Deng Xiuwen | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Ji Zhe | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Jiang Yuliang | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Sun Haitao | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Guo Fuxin | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Fan Jinghong | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Li Weiyan | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | | | Wang Junjie | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | junjiewang_edu@sina.cn |
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| Abstract:: |
| Objective To verify the accuracy and feasibility of radioactive 125I seed implantation assisted by an optical navigation system and a 3D-printing non-coplanar template in the treatment of recurrent head and neck cancers.Methods A total of 12 patients with recurrent head and neck cancer treated with radioactive 125I seed implantation assisted by an optical navigation system and 3D-printing non-coplanar template were enrolled from Dec 2018 to Dec 2019.The pre-plan and post-implant implantation needle number and implanted seed number were recorded.Meanwhile, their dosimetric parameters were compared, including D90, minimum peripheral dose (MPD), V100, V150, V200, conformity index (CI), external index (EI), and the homogeneity index (HI) of the target volume.Results The median lesion volume was 31.5 cm3, the median number of seeds was 61.5, and the median prescription dose was 130 Gy.The means of the pre-plan D90, MPD, V100, V150 and V200 were 134.2, 64.6, 93.3, 75.3 and 39.3 Gy, respectively, while those of post-implant D90, MPD, V100, V150, and V200 were 146.7, 68.94, 97.47,80.40 and 48.30 Gy, respectively,with no statistically significant difference (P>0.05). Meanwhile, there was no statistically significant difference between the pre-plan and post-implantation needle number, implanted seed number, CI, HI, and EI (P>0.05). In terms of postoperative dose quality assessment, eight cases were rated excellent (66.6%) and four cases were rated good (33.3%). Conclusions Radioactive 125I seed implantation assisted by an optical navigation system and 3D-printing non-coplanar template can be accurately performed in the treatment of recurrent head and neck cancer,with good consistency between pre-plan and post-implant dosimetric parameters and thus of prospective potential in clinical application. |
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