| Wang Jiangtao,Guan Quanlin,Ran Juntao.Advances in immunoregulation and mechanism of heavy ion beam radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2020,40(11):888-892 |
| Advances in immunoregulation and mechanism of heavy ion beam radiotherapy |
| Received:February 04, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.11.014 |
| KeyWords:Heavy ion Immunomodulatory Tumor microenvironment Immunogenic cell death |
| FundProject:甘肃省卫生行业科研管理项目（GSWSKY-2019-79） |
| Author Name | Affiliation | E-mail | | Wang Jiangtao | Department of Radiation Oncology, First Hospital of Lanzhou University, First Clinical Medical College of Lanzhou University, Lanzhou 730000, China | | | Guan Quanlin | Department of Oncology Surgery, First Hospital of Lanzhou University, Lanzhou 730000, China | | | Ran Juntao | Department of Radiation Oncology, First Hospital of Lanzhou University, First Clinical Medical College of Lanzhou University, Lanzhou 730000, China | ranjt@lzu.edu.cn |
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| Abstract:: |
| Heavy ion radiation has significant radiological and biological advantages over conventional radiation. While directly killing tumor cells, heavy ion beam can reduce immune escape and promote the initiation and activation of effector T cells by inducing immunogenic death of tumor cells, regulating tumor phenotype, enhancing antigen formulation, and changing tumor microenvironment to regulate the immune response. This article will review the immunomodulatory effect of heavy ion beam and the molecular mechanisms associated with immune checkpoint inhibitor therapy. |
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