| Du Yi,Wang Ruoxi,Yue Haizhen,Zhou Shun,Hu Qiaoqiao,Feng Zhongsu,Wu Hao.Dose response characterization of novel presage sheets for radiotherapy dose verification[J].Chinese Journal of Radiological Medicine and Protection,2020,40(11):862-867 |
| Dose response characterization of novel presage sheets for radiotherapy dose verification |
| Received:April 20, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.11.009 |
| KeyWords:Dose verification Gel dosimeter Presage dosimeter Characterization |
| FundProject:北京市自然科学基金（1202009）；国家自然科学基金（12005007）；北京市属医院科研培育计划项目（PX2019042）；首都卫生发展科研专项（首发2018-4-1027）；教育部科技发展中心产学研创新基金-"智融兴教"基金（2018A01019）；国家重点研发计划（2019YFF01014405） |
| Author Name | Affiliation | E-mail | | Du Yi | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Wang Ruoxi | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Yue Haizhen | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Zhou Shun | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Hu Qiaoqiao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Feng Zhongsu | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | | | Wu Hao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital&Institute, Beijing 100142, China | 13552661030@139.com |
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| Abstract:: |
| Objective To characterize the key dose response properties of the novel presage sheet dosimeters for radiotherapy dose verification, including absorption spectra, linearity, dose range and stability. Methods The same batch of presage sheet dosimeters were irradiated by a radiotherapy linac. The absorption spectra within 400-700 nm were read out with a spectrophotometer, and the R-G-B3 absorption changes read out with a film flatbed scanner was compared before and after irradiation. ResultsAn absorption peak was clearly identified at 628 nm, where absorptions change in high linearity with delivered doses (R2=0.9999). A flat valley region is identified around 490 nm, where dose induced absorption changes were negligible. The readout sensitivity of the R-channel of the flatbed scanner was higher than both in green and blue channels. In the dose range below 10 Gy, the R-channel absorptions are in significant linearity with doses (R2=0.9999), with absorptions change in an obvious quadratic trend in the range beyond 10 Gy (R2=0.9999). The dose range of presage sheets was more than 94.6 Gy. The absorptions were well preserved within 1 h post-irradation, and then are shown to increase gradually, where the increase speeds are dose-related. The post-irradiation integrity of dose falloff gradients are shown with negligible gradient blurring. Conclusions The novel presage sheets shown to have reasonable dose response linearity, large dose range, desirable post-irradiation dose gradient integrity and negligible fractionation effect, which indicates its great potentials in integral dose verification of high-dose and multiple target radiotherapy deliveries. |
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